The discovery of the causes of cardiovascular disease and their prevention; the care of the suffering patients and their cure, requires dedicated physicians and scientists to devote their lifelong work to a health mission without which a civilized society would not survive. Such individuals require years of training in medical science beyond their professional degree under the tutelage and mentoring of established senior medical investigators/teachers working in an environment with exceptional intellectual, technical, and physical resources. At the University of Iowa Cardiovascular Research Center, we have provided a world-renowned training center since 1975, have graduated hundreds of scientists, many of whom are national leaders throughout the USA, and aim to continue to do so for future generations with the renewal of federal support that we are applying for and hope to attain.