2021 Publications

January 31

Age-Related Cognitive Changes as a Function of CAG Repeat in Child and Adolescent Carriers of Mutant Huntingtin. Schultz JL, van der Plas E, Langbehn DR, Conrad AL, Nopoulos PC. Ann Neurol. 2021 Jan 31. doi: 10.1002/ana.26039. Online ahead of print. PMID: 33521985

January 30

Photoreceptor cilia, in contrast to primary cilia, grant entry to a partially assembled BBSome. Hsu Y, Seo S, Sheffield VC. Hum Mol Genet. 2021 Jan 30: ddaa284. doi: 10.1093/hmg/ddaa284. Online ahead of print. PMID: 33517424

January 28

Breast Milk for Term and Preterm Infants-Own Mother's Milk or Donor Milk? Vass RA, Kiss G, Bell EF, Roghair RD, Miseta A, Bódis J, Funke S, Ertl T. Nutrients. 2021 Jan 28; 13(2):424. doi: 10.3390/nu13020424. PMID: 33525560

January 27

Staphylococcal Enterotoxin C Subtypes Are Differentially Associated with Human Infections and Immunobiological Activities. Chuang-Smith ON, Schlievert PM. mSphere. 2021 Jan 27; 6(1):e01153-20. doi: 10.1128/mSphere.01153-20. PMID: 33504664
Three-Dimensional Distance and Coverage Maps in the Assessment of Peritalar Subluxation in Progressive Collapsing Foot Deformity. Dibbern KN, Li S, Vivtcharenko V, Auch E, Lintz F, Ellis SJ, Femino JE, de Cesar Netto C. Foot Ankle Int. 2021 Jan 27: 1071100720983227. doi: 10.1177/1071100720983227. Online ahead of print. PMID: 33504217

January 25

COVID-19 Research Agenda for Healthcare Epidemiology. Mody L, Akinboyo IC, Babcock HM, Bischoff WE, Cheng VC, Chiotos K, Claeys KC, Coffey KC, Diekema DJ, Donskey CJ, Ellingson KD, Gilmartin HM, Gohil SK, Harris AD, Keller SC, Klein EY, Krein SL, Kwon JH, Lauring AS, Livorsi DJ, Lofgren ET, Merrill K, Milstone A, Monsees EA, Morgan DJ, Perri LP, Pfeiffer CD, Rock C, Saint S, Sickbert-Bennett E, Skelton F, Suda KJ, Talbot TR, Vaughn VM, Weber DJ, Wiemken TL, Yassin MH, Ziegler MJ, Anderson DJ; SHEA Research Committee. Infect Control Hosp Epidemiol. 2021 Jan 25:1-81. doi: 10.1017/ice.2021.25. Online ahead of print. PMID: 33487199

January 24

Animal Models and Their Role in Understanding the Pathophysiology of Cystic Fibrosis-Associated Gastrointestinal Lesions. Gibson-Corley KN, Engelhardt JF. Annu Rev Pathol. 2021 Jan 24; 16:51-67. doi: 10.1146/annurev-pathol-022420-105133. PMID: 33497264

January 23

COVID-19 Hospitalization in Adults with Type 1 Diabetes: Results from the T1D Exchange Multicenter Surveillance Study. O'Malley G, Ebekozien O, Desimone M, Pinnaro CT, Roberts A, Polsky S, Noor N, Aleppo G, Basina M, Tansey M, Steenkamp D, Vendrame F, Lorincz I, Mathias P, Agarwal S, Golden L, Hirsch IB, Levy CJ. J Clin Endocrinol Metab. 2021 Jan 23; 106(2):e936-e942. doi: 10.1210/clinem/dgaa825. PMID: 33165563
PATENCY-2 trial of vonapanitase to promote radiocephalic fistula use for hemodialysis and secondary patency. Peden EK, Lucas JF 3rd, Browne BJ, Settle SM, Scavo VA, Bleyer AJ, Ozaki CK, Teruya TH, Wilson SE, Mishler RE, Ferris BL, Hendon KS, Moist L, Dixon BS, Wong MD, Magill M, Lindow F, Gustafson P, Burke SK; PATENCY-2 Investigators. J Vasc Access. 2021 Jan 22: 1129729820985626. doi: 10.1177/1129729820985626. Online ahead of print. PMID: 33482699

January 21

A New Definition of Pain: Update and Implications for Physical Therapy Practice and Rehabilitation Science. Sluka KA, George SZ. Phys Ther. 2021 Jan 22: pzab019. doi: 10.1093/ptj/pzab019. Online ahead of print. PMID: 33481998
Functional Role of the RNA-Binding Protein Rbm24a and Its Target sox2 in Microphthalmia. Brastrom LK, Scott CA, Wang K, Slusarski DC. Biomedicines. 2021 Jan 21; 9(2):100. doi: 10.3390/biomedicines9020100. PMID: 33494192

January 20

Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis. Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA. Thorax. 2021 Jan 20: thoraxjnl-2020-215745. doi: 10.1136/thoraxjnl-2020-215745. Online ahead of print. PMID: 33472968
Targeting of uncontrolled hypertension in the emergency department (TOUCHED): Design of a randomized controlled trial. Prendergast HM, Petzel-Gimbar R, Kitsiou S, Del Rios M, Lara B, Jackson M, Heinert S, Carter BL, Durazo-Arvizu RA, Daviglus M. Contemp Clin Trials. 2021 Jan 20: 106283. doi: 10.1016/j.cct.2021.106283. Online ahead of print. PMID: 33484897

January 19

It takes a village: lessons from collaborative science. Abel ED. J Clin Invest. 2021 Jan 19; 131(2):145962. doi: 10.1172/JCI145962. PMID: 33463544
The sensitivity and specificity of retinal and choroidal folds to distinguish between mild papilloedema and pseudopapilledema. Reggie SN, Avery RA, Bavinger JC, Jivraj I, Alfaro C, Pistilli M, Kohli AA, Liu GT, Shindler KS, Ross AG, Kardon RH, Sibony PA, Tamhankar M. Eye (Lond). 2021 Jan 19. doi: 10.1038/s41433-020-01368-y. Online ahead of print. PMID: 33469131

January 18

Quantitative muscle MRI as a sensitive marker of early muscle pathology in myotonic dystrophy type 1. van der Plas E, Gutmann L, Thedens D, Shields RK, Langbehn K, Guo Z, Sonka M, Nopoulos P. Muscle Nerve. 2021 Jan 18. doi: 10.1002/mus.27174. Online ahead of print. PMID: 33462896

January 16

Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy. Petronek MS, Stolwijk JM, Murray SD, Steinbach EJ, Zakharia Y, Buettner GR, Spitz DR, Allen BG. Redox Biol. 2021 Jan 16:101864. doi: 10.1016/j.redox.2021.101864. Online ahead of print. PMID: 33485837

January 15

Computed Tomography-based Airway Surface Area-to-Volume Ratio for Phenotyping Airway Remodeling in Chronic Obstructive Pulmonary Disease. Bodduluri S, Kizhakke Puliyakote A, Nakhmani A, Charbonnier JP, Reinhardt JM, Bhatt SP. Am J Respir Crit Care Med. 2021 Jan 15; 203(2):185-191. doi: 10.1164/rccm.202004-0951OC. PMID: 32755486
Inorganic nitrate supplementation attenuates conduit artery retrograde and oscillatory shear in older adults. Casey DP, Bock JM. Am J Physiol Heart Circ Physiol. 2021 Jan 15. doi: 10.1152/ajpheart.00843.2020. Online ahead of print. PMID: 33449848
Making sense of missense variants in TTN-related congenital myopathies. Rees M, Nikoopour R, Fukuzawa A, Kho AL, Fernandez-Garcia MA, Wraige E, Bodi I, Deshpande C, Özdemir Ö, Daimagüler HS, Pfuhl M, Holt M, Brandmeier B, Grover S, Fluss J, Longman C, Farrugia ME, Matthews E, Hanna M, Muntoni F, Sarkozy A, Phadke R, Quinlivan R, Oates EC, Schröder R, Thiel C, Reimann J, Voermans N, Erasmus C, Kamsteeg EJ, Konersman C, Grosmann C, McKee S, Tirupathi S, Moore SA, Wilichowski E, Hobbiebrunken E, Dekomien G, Richard I, Van den Bergh P, Domínguez-González C, Cirak S, Ferreiro A, Jungbluth H, Gautel M. Acta Neuropathol. 2021 Jan 15. doi: 10.1007/s00401-020-02257-0. Online ahead of print. PMID: 33449170

January 14

CT image segmentation for inflamed and fibrotic lungs using a multi-resolution convolutional neural network. Gerard SE, Herrmann J, Xin Y, Martin KT, Rezoagli E, Ippolito D, Bellani G, Cereda M, Guo J, Hoffman EA, Kaczka DW, Reinhardt JM. Sci Rep. 2021 Jan 14; 11(1):1455. doi: 10.1038/s41598-020-80936-4. PMID: 33446781

January 13

Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models. Gutierrez WR, Scherer A, McGivney GR, Brockman QR, Knepper-Adrian V, Laverty EA, Roughton GA, Dodd RD. Sci Rep. 2021 Jan 13; 11(1):1098. doi: 10.1038/s41598-020-80216-1. PMID: 33441747
Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice. Gutierrez-Alvarez J, Wang L, Fernandez-Delgado R, Li K, McCray PB Jr, Perlman S, Sola I, Zuñiga S, Enjuanes L. J Virol. 2021 Jan 13; 95(3):e01172-20. doi: 10.1128/JVI.01172-20. Print 2021 Jan 13. PMID: 33144319

January 12

Gene Therapy for Cystic Fibrosis: Lessons Learned and Paths Forward. Choi SH, Engelhardt JF. Mol Ther. 2021 Jan 12: S1525-0016(21)00010-1. doi: 10.1016/j.ymthe.2021.01.010. Online ahead of print. PMID: 33472034

January 11

Dissemination of a telehealth cardiovascular risk service: The CVRS live protocol. Kennelty KA, Engblom NJ, Carter BL, Hollingworth L, Levy BT, Finkelstein RJ, Parker CP, Xu Y, Jackson KL, Dawson JD, Dorsey KK. Contemp Clin Trials. 2021 Jan 11: 106282. doi: 10.1016/j.cct.2021.106282. Online ahead of print. PMID: 33444781

January 6

Comparative Effectiveness and Safety of Direct Oral Anticoagulants in Obese Patients with Atrial Fibrillation. Briasoulis A, Mentias A, Mazur A, Alvarez P, Leira EC, Vaughan Sarrazin MS. Cardiovasc Drugs Ther. 2021 Jan 6. doi: 10.1007/s10557-020-07126-2. Online ahead of print. PMID: 33404923
The neuropsychology of statin intolerance. Robinson JG. Nat Rev Cardiol. 2021 Jan 6. doi: 10.1038/s41569-020-00502-3. Online ahead of print. PMID: 33408360

January 5

Combination therapies for MPNSTs targeting RABL6A-RB1 signaling. Kohlmeyer JL, Gordon DJ, Tanas MR, Dodd RD, Monga V, Darbro BW, Quelle DE. Oncotarget. 2021 Jan 5; 12(1):10-14. doi: 10.18632/oncotarget.27862. eCollection 2021 Jan 5. PMID: 33456709
Refractory infantile high-grade glioma containing TRK-fusion responds to larotrectinib. Waters TW, Moore SA, Sato Y, Dlouhy BJ, Sato M. Pediatr Blood Cancer. 2021 Jan 5: e28868. doi: 10.1002/pbc.28868. Online ahead of print. PMID: 33403813
Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium. Lin BM, Grinde KE, Brody JA, Breeze CE, Raffield LM, Mychaleckyj JC, Thornton TA, Perry JA, Baier LJ, de Las Fuentes L, Guo X, Heavner BD, Hanson RL, Hung YJ, Qian H, Hsiung CA, Hwang SJ, Irvin MR, Jain D, Kelly TN, Kobes S, Lange L, Lash JP, Li Y, Liu X, Mi X, Musani SK, Papanicolaou GJ, Parsa A, Reiner AP, Salimi S, Sheu WH, Shuldiner AR, Taylor KD, Smith AV, Smith JA, Tin A, Vaidya D, Wallace RB, Yamamoto K, Sakaue S, Matsuda K, Kamatani Y, Momozawa Y, Yanek LR, Young BA, Zhao W, Okada Y, Abecasis G, Psaty BM, Arnett DK, Boerwinkle E, Cai J, Yii-Der Chen I, Correa A, Cupples LA, He J, Kardia SL, Kooperberg C, Mathias RA, Mitchell BD, Nickerson DA, Turner ST, Ramachandran VS, Rotter JI, Levy D, Kramer HJ, Köttgen A, Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium, TOPMed Kidney Working Group, Rich SS, Lin DY, Browning SR, Franceschini N. EBioMedicine. 2021 Jan 5; 63:103157. doi: 10.1016/j.ebiom.2020.103157. Online ahead of print. PMID: 33418499

January 4

A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation. Kulkarni CA, Fink BD, Gibbs BE, Chheda PR, Wu M, Sivitz WI, Kerns RJ. J Med Chem. 2021 Jan 4. doi: 10.1021/acs.jmedchem.0c01671. Online ahead of print. PMID: 33395531
Does common cold coronavirus infection protect against severe SARS-CoV-2 disease? Meyerholz DK, Perlman S. J Clin Invest. 2021 Jan 4; 131(1):e144807. doi: 10.1172/JCI144807. PMID: 33216734
Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration. Dalal PJ, Sullivan DP, Weber EW, Sacks DB, Gunzer M, Grumbach IM, Heller Brown J, Muller WA. J Exp Med. 2021 Jan 4; 218(1):e20192378. doi: 10.1084/jem.20192378. PMID: 32970800
Temporal Relationship Between Visual Field, Retinal and Microvascular Pathology Following 125I-Plaque Brachytherapy for Uveal Melanoma. Tamplin MR, Deng W, Garvin MK, Binkley EM, Hyer DE, Buatti JM, Ledolter J, Boldt HC, Kardon RH, Grumbach IM. Invest Ophthalmol Vis Sci. 2021 Jan 4; 62(1):3. doi: 10.1167/iovs.62.1.3. PMID: 33393969

January 2

Racial disparities in survival outcomes following pediatric in-hospital cardiac arrest. Haskell SE, Girotra S, Zhou Y, Zimmerman MB, Del Rios M, Merchant RM, Atkins DL. Resuscitation. 2021 Jan 2: S0300-9572(20)30618-3. doi: 10.1016/j.resuscitation.2020.12.018. Online ahead of print. PMID: 33400929

January 1

Breast cancer endocrine therapy adherence in health professional shortage areas: Unique effects on patients with mental illness. Haskins CB, McDowell BD, Carnahan RM, Fiedorowicz JG, Wallace RB, Smith BJ, Chrischilles EA. J Psychosom Res. 2021 Jan;140:110294. doi: 10.1016/j.jpsychores.2020.110294. Epub 2020 Nov 14. PMID: 33232903
Suicide and suicidality in somatic symptom and related disorders: A systematic review. Torres ME, Löwe B, Schmitz S, Pienta JN, Van Der Feltz-Cornelis C, Fiedorowicz JG. J Psychosom Res. 2021 Jan;140:110290. doi: 10.1016/j.jpsychores.2020.110290. Epub 2020 Nov 10. PMID: 33227556
The Rapid Evolution of Theranostics in Radiation Oncology. Buatti JM, Kiess AP. Semin Radiat Oncol. 2021 Jan; 31(1):1-2. doi: 10.1016/j.semradonc.2020.07.001. PMID: 33246630

February 25

Defining Resilience to Smoking Related Lung Disease: A Modified Delphi Approach from SPIROMICS. Oh AL, Mularski RA, Barjaktarevic I, Barr RG, Bowler RP, Comellas AP, Cooper CB, Criner GJ, Han MK, Hansel NN, Hoffman EA, Kanner RE, Krishnan JA, Paine R 3rd, Parekh TM, Peters SP, Christenson SA, Woodruff PG; SPIROMICS Investigators. Ann Am Thorac Soc. 2021 Feb 25. doi: 10.1513/AnnalsATS.202006-757OC. Online ahead of print. PMID: 33631079
Insights into the pathogenesis of cerebral fusiform aneurysms: high-resolution MRI and computational analysis. Sabotin RP, Varon A, Roa JA, Raghuram A, Ishii D, Nino M, Galloy AE, Patel D, Raghavan ML, Hasan D, Samaniego EA. J Neurointerv Surg. 2021 Feb 25: neurintsurg-2020-017243. doi: 10.1136/neurintsurg-2020-017243. Online ahead of print. PMID: 33632878
QIBA guidance: Computed tomography imaging for COVID-19 quantitative imaging applications. Avila RS, Fain SB, Hatt C, Armato SG 3rd, Mulshine JL, Gierada D, Silva M, Lynch DA, Hoffman EA, Ranallo FN, Mayo JR, Yankelevitz D, Estepar RSJ, Subramaniam R, Henschke CI, Guimaraes A, Sullivan DC. Clin Imaging. 2021 Feb 25; 77:151-157. doi: 10.1016/j.clinimag.2021.02.017. Online ahead of print. PMID: 33684789
The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function. Alghanem AF, Abello J, Maurer JM, Kumar A, Ta CM, Gunasekar SK, Fatima U, Kang C, Xie L, Adeola O, Riker M, Elliot-Hudson M, Minerath RA, Grueter CE, Mullins RF, Stratman AN, Sah R. Elife. 2021 Feb 25; 10:e61313. doi: 10.7554/eLife.61313. Online ahead of print. PMID: 33629656

February 24

Association of Major Dietary Protein Sources With All-Cause and Cause-Specific Mortality: Prospective Cohort Study. Sun Y, Liu B, Snetselaar LG, Wallace RB, Shadyab AH, Kroenke CH, Haring B, Howard BV, Shikany JM, Valdiviezo C, Bao W. J Am Heart Assoc. 2021 Feb 24: e015553. doi: 10.1161/JAHA.119.015553. Online ahead of print. PMID: 33624505
Ca²⁺-Saturated calmodulin binds tightly to the N-terminal domain of A-type fibroblast growth factor homologous factors. Mahling R, Rahlf CR, Hansen SC, Hayden MR, Shea MA. J Biol Chem. 2021 Feb 24: 100458. doi: 10.1016/j.jbc.2021.100458. Online ahead of print. PMID: 33639159
TNF receptor-associated factor 3 restrains B cell receptor signaling in normal and malignant B cells. Whillock AL, Ybarra TK, Bishop GA. J Biol Chem. 2021 Feb 24: 100465. doi: 10.1016/j.jbc.2021.100465. Online ahead of print. PMID: 33639170

February 23

Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Munoz FM, Cramer JP, Dekker CL, Dudley MZ, Graham BS, Gurwith M, Law B, Perlman S, Polack FP, Spergel JM, Van Braeckel E, Ward BJ, Didierlaurent AM, Lambert PH; Brighton Collaboration Vaccine-associated Enhanced Disease Working Group. Vaccine. 2021 Feb 23: S0264-410X(21)00094-3. doi: 10.1016/j.vaccine.2021.01.055. Online ahead of print. PMID: 33637387

February 22

Distinct properties of Ca ²⁺ efflux from brain, heart and liver mitochondria: The effects of Na⁺, Li⁺ and the mitochondria lNa ⁺/Ca ²⁺ exchange inhibitor CGP37157. Rysted JE, Lin Z, Walters GC, Rauckhorst AJ, Noterman M, Liu G, Taylor EB, Strack S, Usachev YM. Cell Calcium. 2021 Feb 22; 96:102382. doi: 10.1016/j.ceca.2021.102382. Online ahead of print. PMID: 33684833
Extended Work Shifts and Neurobehavioral Performance in Resident-Physicians. Rahman SA, Sullivan JP, Barger LK, St Hilaire MA, O'Brien CS, Stone KL, Phillips AJK, Klerman EB, Qadri S, Wright KP Jr, Halbower AC, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Sanderson AL, Zee PC, Landrigan CP, Czeisler CA, Lockley SW; ROSTERS STUDY GROUP. Pediatrics. 2021 Feb 22: e2020009936. doi: 10.1542/peds.2020-009936. Online ahead of print. PMID: 33619044

February 18

Incidence, duration and risk factors associated with delayed and missed diagnostic opportunities related to tuberculosis: a population-based longitudinal study. Miller AC, Arakkal AT, Koeneman S, Cavanaugh JE, Gerke AK, Hornick DB, Polgreen PM. BMJ Open. 2021 Feb 18; 11(2):e045605. doi: 10.1136/bmjopen-2020-045605. PMID: 33602715
Postictal death is associated with tonic phase apnea in a mouse model of SUDEP. Wenker IC, Teran FA, Wengert ER, Wagley PK, Panchal PS, Blizzard EA, Saraf P, Wagnon JL, Goodkin HP, Meisler MH, Richerson GB, Patel MK. Ann Neurol. 2021 Feb 18. doi: 10.1002/ana.26053. Online ahead of print. PMID: 33604927

February 12

FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu AT, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. Am J Physiol Heart Circ Physiol. 2021 Feb 12. doi: 10.1152/ajpheart.00838.2020. Online ahead of print. PMID: 33577435
Seizure Clusters, Seizure Severity Markers, and SUDEP Risk. Ochoa-Urrea M, Lacuey N, Vilella L, Zhu L, Jamal-Omidi S, Rani MRS, Hampson JP, Dayyani M, Hampson J, Hupp NJ, Tao S, Sainju RK, Friedman D, Nei M, Scott C, Allen L, Gehlbach BK, Reick-Mitrisin V, Schuele S, Ogren J, Harper RM, Diehl B, Bateman LM, Devinsky O, Richerson GB, Zhang GQ, Lhatoo SD. Front Neurol. 2021 Feb 12; 12:643916. doi: 10.3389/fneur.2021.643916. eCollection 2021. PMID: 33643216

February 11

Mechanisms of Frank-Starling law of the heart and stretch activation in striated muscles may have a common molecular origin. Kawai M, Jin JP. J Muscle Res Cell Motil. 2021 Feb 11. doi: 10.1007/s10974-020-09595-2. Online ahead of print. PMID: 33575955

February 10

Concentration of Lp(a) (Lipoprotein[a]) in Aneurysm Sac Is Associated With Wall Enhancement of Unruptured Intracranial Aneurysm. Ishii D, Zanaty M, Roa JA, Li L, Lu Y, Sabotin R, Allan L, Samaniego EA, Hasan DM. Stroke. 2021 Feb 10: STROKEAHA120032304. doi: 10.1161/STROKEAHA.120.032304. Online ahead of print. PMID: 33563021
Effects of fluoride intake on cortical and trabecular bone microstructure at early adulthood using multi-row detector computed tomography (MDCT). Saha PK, Oweis RR, Zhang X, Letuchy E, Eichenberger-Gilmore JM, Burns TL, Warren JJ, Janz KF, Torner JC, Snetselaar LG, Levy SM. Bone. 2021 Feb 10; 146:115882. doi: 10.1016/j.bone.2021.115882. Online ahead of print. PMID: 33578032
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study. Mauras N, Buckingham B, White NH, Tsalikian E, Weinzimer SA, Jo B, Cato A, Fox LA, Aye T, Arbelaez AM, Hershey T, Tansey M, Tamborlane W, Foland-Ross LC, Shen H, Englert K, Mazaika P, Marzelli M, Reiss AL; Diabetes Research in Children Network (DirecNet). Diabetes Care. 2021 Feb 10: dc202125. doi: 10.2337/dc20-2125. Online ahead of print. PMID: 33568403
Temporal Trends of Candidemia Incidence Rates and Potential Contributions of Infection Control Initiatives over 18 Years within the US Veteran Health Administration System: A Joinpoint Time-Series Analysis. Suzuki H, Perencevich EN, Diekema DJ, Livorsi DJ, Nair R, Kralovic SM, Roselle GA, Goto M. Clin Infect Dis. 2021 Feb 10: ciab105. doi: 10.1093/cid/ciab105. Online ahead of print. PMID: 33564858

February 9

A comparative study of transradial versus transfemoral approach for flow diversion. Weinberg JH, Sweid A, Hammoud B, Asada A, Greco-Hiranaka C, Piper K, Gooch MR, Tjoumakaris S, Herial N, Hasan D, Zarzour H, Rosenwasser RH, Jabbour P. Neuroradiology. 2021 Feb 9. doi: 10.1007/s00234-021-02672-4. Online ahead of print. PMID: 33560470

February 6

Hypertrophic cardiomyopathy associated E22K mutation in myosin regulatory light chain decreases calcium-activated tension and stiffness and reduces myofilament Ca2+ sensitivity. Zhang J, Wang L, Kazmierczak K, Yun H, Szczesna-Cordary D, Kawai M. FEBS J. 2021 Feb 6. doi: 10.1111/febs.15753. Online ahead of print. PMID: 33548158
N-Alkyl triphenylvinylpyridinium conjugated dihydroartemisinin perturbs mitochondrial functions resulting in enhanced cancer versus normal cell toxicity. Varmazyad M, Modi MM, Kalen AL, Sarsour EH, Wagner B, Du J, Schultz MK, Buettner GR, Pigge FC, Goswami PC. Free Radic Biol Med. 2021 Feb 6: S0891-5849(21)00067-8. doi: 10.1016/j.freeradbiomed.2021.01.050. Online ahead of print. PMID: 33561488
VDD ICD Systems: Can They Keep Us Afloat in a Sea of Dual Chamber Devices? Powers EM, Mazur A. Trends Cardiovasc Med. 2021 Feb 6: S1050-1738(21)00015-3. doi: 10.1016/j.tcm.2021.01.008. Online ahead of print. PMID: 33561580

February 5

Autonomic dysregulation as an early pathologic feature of Huntington Disease. Schultz JL, Harshman LA, Kamholz JA, Nopoulos PC. Auton Neurosci. 2021 Mar; 231:102775. doi: 10.1016/j.autneu.2021.102775. Epub 2021 Feb 5. PMID: 33571915
Encapsulating Polyethyleneimine-DNA Nanoplexes into PEGylated Biodegradable Microparticles Increases Transgene Expression In Vitro and Reduces Inflammatory Responses In Vivo. Terry TL, Givens BE, Adamcakova-Dodd A, Thorne PS, Rodgers VGJ, Salem AK. AAPS PharmSciTech. 2021 Feb 9; 22(2):69. doi: 10.1208/s12249-021-01932-z. PMID: 33565009
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort. Opron K, Begley LA, Erb-Downward JR, Freeman C, Madapoosi S, Alexis NE, Barjaktarevic I, Graham Barr R, Bleecker ER, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper DJ, Doerschuk CM, Dransfield MT, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Krishnan J, O'Neal WK, Ortega VE, Paine R 3rd, Peters SP, Michael Wells J, Woodruff PG, Martinez FJ, Curtis JL, Huffnagle GB, Huang YJ. NPJ Biofilms Microbiomes. 2021 Feb 5; 7(1):14. doi: 10.1038/s41522-021-00185-9. PMID: 33547327

February 4

Autophagy stimulation reduces ocular hypertension in murine glaucoma model via autophagic degradation of mutant myocilin. Kasetti RB, Maddineni P, Kiehlbauch CC, Patil S, Searby CC, Levine B, Sheffield VC, Zode GS. JCI Insight. 2021 Feb 4: 143359. doi: 10.1172/jci.insight.143359. Online ahead of print. PMID: 33539326
Discrepancies in decision making preferences between parents and surgeons in pediatric surgery. Carlisle EM, Klipowicz CJ, Shinkunas LA, Scherer AM, Kaldjian LC. BMC Med Inform Decis Mak. 2021 Feb 4; 21(1):42. doi: 10.1186/s12911-021-01414-z. PMID: 33541347

February 3

Epstein-Barr Functional Mimicry: Pathogenicity of Oncogenic Latent Membrane Protein-1 in Systemic Lupus Erythematosus and Autoimmunity. Munroe ME, Anderson JR, Gross TF, Stunz LL, Bishop GA, James JA. Front Immunol. 2021 Feb 3; 11:606936. doi: 10.3389/fimmu.2020.606936. eCollection 2020. PMID: 33613527
On-demand biomanufacturing of protective conjugate vaccines. Stark JC, Jaroentomeechai T, Moeller TD, Hershewe JM, Warfel KF, Moricz BS, Martini AM, Dubner RS, Hsu KJ, Stevenson TC, Jones BD, DeLisa MP, Jewett MC. Sci Adv. 2021 Feb 3; 7(6):eabe9444. doi: 10.1126/sciadv.abe9444. Print 2021 Feb. PMID: 33536221

February 1

March 31

17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Harrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors MA, Lopez-Cruzan M, Macchiarini F, Nelson JF, Bitto A, Sindler AL, Cortopassi G, Kavanagh K, Leng L, Bucala R, Rosenthal N, Salmon A, Stearns TM, Bogue M, Miller RA. Aging Cell. 2021 Mar 31: e13328. doi: 10.1111/acel.13328. Online ahead of print. PMID: 33788371
V-type ATPase Mediates Airway Surface Liquid Acidification in Pig Small Airway Epithelial Cells. Li X, Villacreses R, Thornell IM, Noriega J, Mather S, Brommel CM, Lu L, Zabner A, Ehler A, Meyerholz DK, Stoltz DA, Zabner J. Am J Respir Cell Mol Biol. 2021 Mar 31. doi: 10.1165/rcmb.2020-0349OC. Online ahead of print. PMID: 33789071

March 30

Did Edgar Degas have Stargardt disease? Karcioglu ZA, Stone EM, Marmor MF. Ophthalmic Genet. 2021 Mar 30: 1-3. doi: 10.1080/13816810.2021.1904418. Online ahead of print. PMID: 33781147
Perilipin2 down-regulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria. Mishra A, Liu S, Promes J, Harata M, Sivitz WI, Fink BD, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens SB, King TH, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum JA, Imai Y. JCI Insight. 2021 Mar 30: 144341. doi: 10.1172/jci.insight.144341. Online ahead of print. PMID: 33784258

March 27

Amylin analog pramlintide induces migraine-like attacks in patients. Ghanizada H, Al-Karagholi MA, Walker CS, Arngrim N, Rees T, Petersen J, Siow A, Mørch-Rasmussen M, Tan S, O'Carroll SJ, Harris P, Skovgaard LT, Jørgensen NR, Brimble M, Waite JS, Rea BJ, Sowers LP, Russo AF, Hay DL, Ashina M. Ann Neurol. 2021 Mar 27. doi: 10.1002/ana.26072. Online ahead of print. PMID: 33772845

March 26

Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia. Jenkins MW, Khalid F, Baby SM, May WJ, Young AP, Bates JN, Cheng F, Seckler JM, Lewis SJ. Sci Rep. 2021 Mar 26; 11(1):6985. doi: 10.1038/s41598-021-86458-x. PMID: 33772077
Head-Down Tilt Bed Rest Studies as a Terrestrial Analog for Spaceflight Associated Neuro-Ocular Syndrome. Ong J, Lee AG, Moss HE. Front Neurol. 2021 Mar 26; 12:648958. doi: 10.3389/fneur.2021.648958. eCollection 2021. PMID: 33841315 Free PMC article. Review.
REGULATION OF CEREBRAL BLOOD FLOW IN HUMANS: PHYSIOLOGY AND CLINICAL IMPLICATIONS OF AUTOREGULATION. Claassen JAHR, Thijssen DHJ, Panerai RB, Faraci FM. Physiol Rev. 2021 Mar 26. doi: 10.1152/physrev.00022.2020. Online ahead of print. PMID: 33769101
The 2021 AAAAI Foundation Faculty Development awardees. Ballas ZK. J Allergy Clin Immunol. 2021 May;147(5):1629-1633. doi: 10.1016/j.jaci.2021.03.021. Epub 2021 Mar 26. PMID: 33773974 No abstract available.

March 25

Activated B lymphocytes and tumor cell lysate as an effective cellular cancer vaccine. Oxley KL, Hanson BM, Zani AN, Bishop GA. Cancer Immunol Immunother. 2021 Mar 25. doi: 10.1007/s00262-021-02914-7. Online ahead of print. PMID: 33765210
A Surgical Window Trial Evaluating Medroxyprogesterone Acetate with or without Entinostat in Patients with Endometrial Cancer and Validation of Biomarkers of Cellular Response. Duska LR, Filiaci VL, Walker JL, Holman LL, Hill EK, Moore RG, Ring KL, Pearl ML, Muller CY, Kushnir CL, Lankes HA, Samuelson MI, Carrick KS, Rajan A, Rodgers WH, Kohn EC, Piekarz R, Leslie KK. Clin Cancer Res. 2021 Mar 25. doi: 10.1158/1078-0432.CCR-20-4618. Online ahead of print. PMID: 33766814

March 24

Palliative care consultation in patients with Staphylococcus aureus bacteremia. Kobayashi T, Salinas JL, Ten Eyck P, Chen B, Ando T, Inagaki K, Alsuhaibani M, Auwaerter PG, Molano I, Diekema DJ. Palliat Med. 2021 Mar 24: 269216321999574. doi: 10.1177/0269216321999574. Online ahead of print. PMID: 33757367
Melanoma Brain Metastases in the Era of Targeted Therapy and Checkpoint Inhibitor Therapy. Rieth JM, Swami U, Mott SL, Zanaty M, Henry MD, Bossler AD, Greenlee JD, Zakharia Y, Vanneste M, Jennings B, Milhem MM.Cancers (Basel). 2021 Mar 24;13(7):1489. doi: 10.3390/cancers13071489. PMID: 33804910

March 23

Bisphenol F exposure in adolescent heterogeneous stock (HS) rats affects growth and adiposity. Wagner VA, Clark KC, Carrillo-Sáenz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Woods LCS, Lehmler HJ, Kwitek AE. Toxicol Sci. 2021 Mar 23: kfab035. doi: 10.1093/toxsci/kfab035. Online ahead of print. PMID: 33755180
NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD. Mahling R, Hovey L, Isbell HM, Marx DC, Miller MS, Kilpatrick AM, Weaver LD, Yoder JB, Kim EH, Andresen CNJ, Li S, Shea MA. Structure. 2021 Mar 23: S0969-2126(21)00075-7. doi: 10.1016/j.str.2021.03.002. Online ahead of print. PMID: 33770503
Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium. van de Locht M, Donkervoort S, de Winter JM, Conijn S, Begthel L, Kusters B, Mohassel P, Hu Y, Medne L, Quinn C, Moore SA, Foley AR, Seo G, Hwee DT, Malik FI, Irving T, Ma W, Granzier H, Kamsteeg EJ, Immadisetty K, Kekenes-Huskey P, Pinto JR, Voermans N, Bönnemann CG, Ottenheijm CA. J Clin Invest. 2021 Mar 23: 145700. doi: 10.1172/JCI145700. Online ahead of print. PMID: 33755597
Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women. Reeves KW, Vieyra G, Grimes NP, Meliker J, Jackson RD, Wactawski-Wende J, Wallace R, Zoeller RT, Bigelow C, Hankinson SE, Manson JE, Cauley JA, Calafat AM. J Clin Endocrinol Metab. 2021 Mar 23: dgab189. doi: 10.1210/clinem/dgab189. Online ahead of print. PMID: 33754148

March 22

AP-2alpha Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer. Beck AC, Cho E, White JR, Paemka L, Li T, Gu VW, Thompson DT, Koch KE, Franke C, Gosse M, Wu VT, Landers SR, Pamatmat AJ, Kulak MV, Weigel RJ. Mol Cancer Res. 2021 Mar 22: molcanres.MCR-20-0867-E.2020. doi: 10.1158/1541-7786.MCR-20-0867. Online ahead of print. PMID: 33753551
Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy. Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. Cancer Res. 2021 Mar 22: canres.2870.2020. doi: 10.1158/0008-5472.CAN-20-2870. Online ahead of print. PMID: 33753374

March 20

Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant. Edara VV, Norwood C, Floyd K, Lai L, Davis-Gardner ME, Hudson WH, Mantus G, Nyhoff LE, Adelman MW, Fineman R, Patel S, Byram R, Gomes DN, Michael G, Abdullahi H, Beydoun N, Panganiban B, McNair N, Hellmeister K, Pitts J, Winters J, Kleinhenz J, Usher J, O'Keefe JB, Piantadosi A, Waggoner JJ, Babiker A, Stephens DS, Anderson EJ, Edupuganti S, Rouphael N, Ahmed R, Wrammert J, Suthar MS. Cell Host Microbe. 2021 Mar 20:S1931-3128(21)00137-2. doi: 10.1016/j.chom.2021.03.009. Online ahead of print. PMID: 33798491 Free PMC article.

March 19

March 18

Neurocognitive Features of Motor Premanifest Individuals With Myotonic Dystrophy Type 1. van der Plas E, Koscik TR, Magnotta V, Cumming SA, Monckton D, Gutmann L, Nopoulos P. Neurol Genet. 2021 Mar 18;7(2):e577. doi: 10.1212/NXG.0000000000000577. eCollection 2021 Apr. PMID: 33912661
Perspective: Impact of the National Academy of Sciences, Engineering, and Medicine Report on the Process for the 2020 Dietary Guidelines Advisory Committee. Schneeman BO, Ard JD, Boushey CJ, Bailey RL, Novotny R, Snetselaar LG, de Jesus JM, Stoody EE. Adv Nutr. 2021 Mar 18: nmab023. doi: 10.1093/advances/nmab023. Online ahead of print. PMID: 33734285

March 17

Viewpoint: Time to stop treating the heart as a single organ? Vasilyev M, Berschel MR, Tomasson MH, Bates ML. Exp Physiol. 2021 Mar 17. doi: 10.1113/EP089497. Online ahead of print. PMID: 33728739

March 16

Creation and validation of models to predict response to primary treatment in serous ovarian cancer. Gonzalez Bosquet J, Devor EJ, Newtson AM, Smith BJ, Bender DP, Goodheart MJ, McDonald ME, Braun TA, Thiel KW, Leslie KK. Sci Rep. 2021 Mar 16; 11(1):5957. doi: 10.1038/s41598-021-85256-9. PMID: 33727600
Dual-process brain mitochondria isolation preserves function and clarifies protein composition. Noterman MF, Chaubey K, Lin-Rahardja K, Rajadhyaksha AM, Pieper AA, Taylor EB. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2019046118. doi: 10.1073/pnas.2019046118. PMID: 33836587 Free PMC article.
Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study. Liu B, Du Y, Wu Y, Snetselaar LG, Wallace RB, Bao W. BMJ. 2021 Mar 16; 372:n365. doi: 10.1136/bmj.n365. PMID: 33727242

March 15

Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil.Coppey L, Obrosov A, Shevalye H, Davidson E, Paradee W, Yorek MA. J Diabetes Res. 2021 Mar 15;2021:5564477. doi: 10.1155/2021/5564477. eCollection 2021.PMID: 33816635 Free PMC article.

March 13

Generation-based study of airway remodeling in smokers with normal-looking CT with normalization to control inter-subject variability. Chae KJ, Jin GY, Choi J, Lee CH, Choi S, Choi H, Park J, Lin CL, Hoffman EA. Eur J Radiol. 2021 Mar 13; 138:109657. doi: 10.1016/j.ejrad.2021.109657. Online ahead of print. PMID: 33773402
Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats. Helke KL, Meyerholz DK, Beck AP, Burrough ER, Derscheid RJ, Löhr C, McInnes EF, Scudamore CL, Brayton CF. ILAR J. 2021 Mar 13: ilab005. doi: 10.1093/ilar/ilab005. Online ahead of print. PMID: 33712827

March 12

BBSome Ablation in SF1 Neurons Causes Obesity without the Comorbidities. Rouabhi M, Guo DF, Morgan DA, Zhu Z, López M, Zingman L, Grobe JL, Rahmouni K. Mol Metab. 2021 Mar 12: 101211. doi: 10.1016/j.molmet.2021.101211. Online ahead of print. PMID: 33722691
Effects of menopausal hormone therapy on erythrocyte n-3 and n-6 PUFA concentrations in the Women's Health Initiative randomized trial. Harris WS, Tintle NL, Manson JE, Metherel AH, Robinson JG. Am J Clin Nutr. 2021 Mar 12: nqaa443. doi: 10.1093/ajcn/nqaa443. Online ahead of print. PMID: 33710263

March 11

Smooth Muscle Cell-Specific PKM (Pyruvate Kinase M) 2 Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia. Jain M, Dhanesha N, Doddapattar P, Nayak MK, Guo L, Cornelissen A, Lentz SR, Finn AV, Chauhan AK. Arterioscler Thromb Vasc Biol. 2021 Mar 11: ATVBAHA121316021. doi: 10.1161/ATVBAHA.121.316021. Online ahead of print. PMID: 33691477
Ventilated Patients With COVID-19 Show Airflow Obstruction. Koppurapu VS, Puliaiev M, Doerschug KC, Schmidt GA. J Intensive Care Med. 2021 Mar 11: 8850666211000601. doi: 10.1177/08850666211000601. Online ahead of print. PMID: 33706592

March 10

Association of CAG Repeat Length in the Huntington Gene With Cognitive Performance in Young Adults. Schultz JL, Saft C, Nopoulos PC. Neurology. 2021 Mar 10:10.1212/WNL.0000000000011823. doi: 10.1212/WNL.0000000000011823. Online ahead of print. PMID: 33692166

March 9

A Proposed Framework for Identifying Nutrients and Food Components of Public Health Relevance in the Dietary Guidelines for Americans. Bailey RL, Ard JD, Davis TA, Naimi TS, Schneeman BO, Stang JS, Dewey KG, Donovan SM, Novotny R, Snetselaar LG, de Jesus J, Casavale KO, Pannucci T, Stoody EE. J Nutr. 2021 Mar 9: nxaa459. doi: 10.1093/jn/nxaa459. Online ahead of print. PMID: 33693925

March 8

Neutrophil-derived extracellular vesicles modulate the phenotype of naïve human neutrophils. Amjadi MF, Avner BS, Greenlee-Wacker MC, Horswill AR, Nauseef WM. J Leukoc Biol. 2021 Mar 8. doi: 10.1002/JLB.3AB0520-339RR. Online ahead of print. PMID: 33682200

March 5

Bacterial, Archaea, and Viral Transcripts (BAVT) Expression in Gynecological Cancers and Correlation with Regulatory Regions of the Genome. Gonzalez-Bosquet J, Pedra-Nobre S, Devor EJ, Thiel KW, Goodheart MJ, Bender DP, Leslie KK. Cancers (Basel). 2021 Mar 5;13(5):1109. doi: 10.3390/cancers13051109. PMID: 33807612 Free PMC article.

March 4

Ectopic expression of BBS1 rescues male infertility, but not retinal degeneration, in a BBS1 mouse model. Cring MR, Meyer KJ, Searby CC, Hedberg-Buenz A, Cave M, Anderson MG, Wang K, Sheffield VC. Gene Ther. 2021 Mar 4. doi: 10.1038/s41434-021-00241-1. Online ahead of print. PMID: 33664503
Stay or go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice. Keyes AL, Kim YC, Bosch PJ, Usachev YM, Aldridge GM. Cell Calcium. 2021 Mar 4; 96:102388. doi: 10.1016/j.ceca.2021.102388. Online ahead of print. PMID: 33740531

March 3

n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies. Qian F, Ardisson Korat AV, Imamura F, Marklund M, Tintle N, Virtanen JK, Zhou X, Bassett JK, Lai H, Hirakawa Y, Chien KL, Wood AC, Lankinen M, Murphy RA, Samieri C, Pertiwi K, de Mello VD, Guan W, Forouhi NG, Wareham N, Hu ICFB, Riserus U, Lind L, Harris WS, Shadyab AH, Robinson JG, Steffen LM, Hodge A, Giles GG, Ninomiya T, Uusitupa M, Tuomilehto J, Lindström J, Laakso M, Siscovick DS, Helmer C, Geleijnse JM, Wu JHY, Fretts A, Lemaitre RN, Micha R, Mozaffarian D, Sun Q; Fatty Acids and Outcomes Research Consortium (FORCE). Diabetes Care. 2021 Mar 3: dc202426. doi: 10.2337/dc20-2426. Online ahead of print. PMID: 33658295
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells. Zheng J, Wang Y, Li K, Meyerholz DK, Allamargot C, Perlman S. J Infect Dis. 2021 Mar 3; 223(5):785-795. doi: 10.1093/infdis/jiaa753. PMID: 33277988

March 2

PrecISE: Precision Medicine in Severe Asthma An Adaptive Platform Trial with Biomarker Ascertainment. Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A. J Allergy Clin Immunol. 2021 Mar 2: S0091-6749(21)00352-3. doi: 10.1016/j.jaci.2021.01.037. Online ahead of print. PMID: 33667479

March 1

April 30

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C. Cell Metab. 2021 Apr 30:S1550-4131(21)00173-X. doi: 10.1016/j.cmet.2021.04.007. Online ahead of print. PMID: 33951475

April 29

Association between Menopausal Hormone Therapy and Incidence of Psoriasis: A Secondary Analysis from the Women's Health Initiative Randomized Clinical Trials. Chan AA, Noguti J, Yang CT, Feldman SR, Wallace RB, Shadyab AH, Manson JE, Aragaki AK, Chlebowski RT, Lee DJ. Br J Dermatol. 2021 Apr 29. doi: 10.1111/bjd.20410. Online ahead of print. PMID: 33913153
Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length. McGroder CF, Zhang D, Choudhury MA, Salvatore MM, D'Souza BM, Hoffman EA, Wei Y, Baldwin MR, Garcia CK. Thorax. 2021 Apr 29 :thoraxjnl-2021-217031. doi: 10.1136/thoraxjnl-2021-217031. Online ahead of print.PMID: 33927016

April 28

Exclusion of Expert Contributors From Authorship Limits the Quality of Scientific Articles. Meyerholz DK, Adissu HA, Carvalho T, Atkins HM, Rissi DR, Beck AP, Ward JM, Piersigilli A. Vet Pathol. 2021 Apr 28:3009858211011943. doi: 10.1177/03009858211011943. Online ahead of print. PMID: 33906549
Radiomics Detection of Pulmonary Hypertension via Texture-Based Assessments of Cardiac MRI: A Machine-Learning Model Comparison-Cardiac MRI Radiomics in Pulmonary Hypertension. Priya S, Aggarwal T, Ward C, Bathla G, Jacob M, Gerke A, Hoffman EA, Nagpal P. J Clin Med. 2021 Apr 28;10(9):1921. doi: 10.3390/jcm10091921. PMID: 33925262
Sex-specific cytokine responses and neurocognitive outcome after blood transfusions in preterm infants. Benavides A, Bell EF, Georgieff MK, Josephson CD, Stowell SR, Feldman HA, Nalbant D, Tereshchenko A, Sola-Visner M, Nopoulos P. Pediatr Res. 2021 Apr 28. doi: 10.1038/s41390-021-01536-0. Online ahead of print. PMID: 33911194

April 27

Cigarette Smoking and Longitudinal Associations With Blood Pressure: The CARDIA Study. Luehrs RE, Zhang D, Pierce GL, Jacobs DR Jr, Kalhan R, Whitaker KM. J Am Heart Assoc. 2021 Apr 27:e019566. doi: 10.1161/JAHA.120.019566. Online ahead of print. PMID: 33902307
Disparities in access to food and chronic obstructive pulmonary disease (COPD)-related outcomes: a cross-sectional analysis. Moughames E, Woo H, Galiatsatos P, Romero-Rivero K, Raju S, Tejwani V, Hoffman EA, Comellas AP, Ortega VE, Parekh T, Krishnan JA, Drummond MB, Couper D, Buhr RG, Paine R, Kaufman JD, Paulin LM, Putcha N, Hansel NN. BMC Pulm Med. 2021 Apr 27;21(1):139. doi: 10.1186/s12890-021-01485-8. PMID: 33906617
Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells. Cohen KW, Linderman SL, Moodie Z, Czartoski J, Lai L, Mantus G, Norwood C, Nyhoff LE, Edara VV, Floyd K, De Rosa SC, Ahmed H, Whaley R, Patel SN, Prigmore B, Lemos MP, Davis CW, Furth S, O'Keefe J, Gharpure MP, Gunisetty S, Stephens KA, Antia R, Zarnitsyna VI, Stephens DS, Edupuganti S, Rouphael N, Anderson EJ, Mehta AK, Wrammert J, Suthar MS, Ahmed R, McElrath MJ. medRxiv. 2021 Apr 27:2021.04.19.21255739. doi: 10.1101/2021.04.19.21255739. Preprint. PMID: 33948610

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Pratte KA, Curtis JL, Kechris K, Couper D, Cho MH, Silverman EK, DeMeo DL, Sciurba FC, Zhang Y, Ortega VE, O'Neal WK, Gillenwater LA, Lynch DA, Hoffman EA, Newell JD Jr, Comellas AP, Castaldi PJ, Miller BE, Pouwels SD, Hacken NHTT, Bischoff R, Klont F, Woodruff PG, Paine R, Barr RG, Hoidal J, Doerschuk CM, Charbonnier JP, Sung R, Locantore N, Yonchuk JG, Jacobson S, Tal-Singer R, Merrill D, Bowler RP. Respir Res. 2021 Apr 27;22(1):127. doi: 10.1186/s12931-021-01686-z. PMID: 33906653

April 26

Risk-Standardized Home Time as a Novel Hospital Performance Metric for Pneumonia Hospitalization Among Medicare Beneficiaries: a Retrospective Cohort Study. Nair R, Gao Y, Vaughan-Sarrazin MS, Perencevich E, Girotra S, Pandey A. J Gen Intern Med. 2021 Apr 26. doi: 10.1007/s11606-021-06712-w. Online ahead of print. PMID: 33904043
The first few days of a SARS-CoV-2 infection viewed at single-cell resolution. Gallagher T, McCray PB Jr. PLoS Biol. 2021 Apr 26;19(4):e3001217. doi: 10.1371/journal.pbio.3001217. Online ahead of print. PMID: 33901166

April 25

Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. Free Radic Biol Med. 2021 Apr 25:S0891-5849(21)00224-0. doi: 10.1016/j.freeradbiomed.2021.03.046. Online ahead of print. PMID: 33910093
Transduction of Pig Small Airway Epithelial Cells and Distal Lung Progenitor Cells by AAV4. Chen OG, Mather SE, Brommel CM, Hamilton BA, Ehler A, Villacreses R, Girgis RE, Abou Alaiwa M, Stoltz DA, Zabner J, Li X. Cells. 2021 Apr 25;10(5):1014. doi: 10.3390/cells10051014. PMID: 33923029

April 23

Mining Metabolomics in Mitral Valve Disease. Scheibe EL, Grueter CE. J Am Heart Assoc. 2021 Apr 23:e020726. doi: 10.1161/JAHA.121.020726. Online ahead of print. PMID: 33890481 No abstract available.
Radiomics-based differentiation between glioblastoma and primary central nervous system lymphoma: a comparison of diagnostic performance across different MRI sequences and machine learning techniques. Bathla G, Priya S, Liu Y, Ward C, Le NH, Soni N, Maheshwarappa RP, Monga V, Zhang H, Sonka M. Eur Radiol. 2021 Apr 23. doi: 10.1007/s00330-021-07845-6. Online ahead of print. PMID: 33890149

April 22

A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment. Pak TK, Carter CS, Zhang Q, Huang SC, Searby C, Hsu Y, Taugher RJ, Vogel T, Cychosz CC, Genova R, Moreira NN, Stevens H, Wemmie JA, Pieper AA, Wang K, Sheffield VC. PLoS Genet. 2021 Apr 22;17(4):e1009484. doi: 10.1371/journal.pgen.1009484. eCollection 2021 Apr. PMID: 33886537
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Harris WS, Tintle NL, Imamura F, Qian F, Korat AVA, Marklund M, Djoussé L, Bassett JK, Carmichael PH, Chen YY, Hirakawa Y, Küpers LK, Laguzzi F, Lankinen M, Murphy RA, Samieri C, Senn MK, Shi P, Virtanen JK, Brouwer IA, Chien KL, Eiriksdottir G, Forouhi NG, Geleijnse JM, Giles GG, Gudnason V, Helmer C, Hodge A, Jackson R, Khaw KT, Laakso M, Lai H, Laurin D, Leander K, Lindsay J, Micha R, Mursu J, Ninomiya T, Post W, Psaty BM, Risérus U, Robinson JG, Shadyab AH, Snetselaar L, Sala-Vila A, Sun Y, Steffen LM, Tsai MY, Wareham NJ, Wood AC, Wu JHY, Hu F, Sun Q, Siscovick DS, Lemaitre RN, Mozaffarian D; Fatty Acids and Outcomes Research Consortium (FORCE). Nat Commun. 2021 Apr 22;12(1):2329. doi: 10.1038/s41467-021-22370-2. PMID: 33888689
Wearable Monitors Facilitate Exercise in Adult and Pediatric Stem Cell Transplant. Pottebaum E, Warmoth A, Ayyappan S, Dickens DS, Jethava Y, Modi A, Tomasson MH, Carr LJ, Bates ML. Exerc Sport Sci Rev. 2021 Apr 22. doi: 10.1249/JES.0000000000000258. Online ahead of print. PMID: 33927164

April 21

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R 3rd, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J; NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS); NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. Genome Med. 2021 Apr 21;13(1):66. doi: 10.1186/s13073-021-00866-2. PMID: 33883027 Free PMC article.

April 20

Biomarker-Calibrated Macronutrient Intake and Chronic Disease Risk among Postmenopausal Women. Prentice RL, Pettinger M, Neuhouser ML, Raftery D, Zheng C, Gowda GAN, Huang Y, Tinker LF, Howard BV, Manson JE, Wallace R, Mossavar-Rahmani Y, Johnson KC, Lampe JW. J Nutr. 2021 Apr 20:nxab091. doi: 10.1093/jn/nxab091. Online ahead of print. PMID: 33880504

April 19

COVID-19 Vaccination Preparedness Policies in U.S. Hospitals. Beekmann SE, Babcock HM, Rasnake MS, Talbot TR, Polgreen PM. Infect Control Hosp Epidemiol. 2021 Apr 19:1-13. doi: 10.1017/ice.2021.181. Online ahead of print. PMID: 33866989
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD. Roboon J, Hattori T, Ishii H, Takarada-Iemata M, Nguyen DT, Heer CD, O'Meally D, Brenner C, Yamamoto Y, Okamoto H, Higashida H, Hori O. J Neurochem. 2021 Apr 19. doi: 10.1111/jnc.15367. Online ahead of print. PMID: 33871064
Pharmacological and cell-specific genetic PI3Kα inhibition worsens cardiac remodeling after myocardial infarction. Chen X, Zhabyeyev P, Azad AK, Vanhaesebroeck B, Grueter CE, Murray AG, Kassiri Z, Oudit GY. J Mol Cell Cardiol. 2021 Apr 19;157:17-30. doi: 10.1016/j.yjmcc.2021.04.004. Online ahead of print. PMID: 33887328

April 17

Recurrent Stent Thrombosis: An Interventionalist's Nightmare. Panaich SS, Girotra S. J Am Heart Assoc. 2021 Apr 17:e020728. doi: 10.1161/JAHA.121.020728. Online ahead of print. PMID: 33870700

April 16

Associations of D-dimer with CT Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study. Kim JS, Anderson MR, Bernstein EJ, Oelsner EC, Raghu G, Noth I, Tsai MY, Salvatore M, Austin JHM, Hoffman EA, Barr RG, Podolanczuk AJ. Ann Am Thorac Soc. 2021 Apr 16. doi: 10.1513/AnnalsATS.202012-1557OC. Online ahead of print. PMID: 33861685
Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate. Du J, Carroll RS, Steers GJ, Wagner BA, O'Leary BR, Jensen CS, Buettner GR, Cullen JJ. Antioxidants (Basel). 2021 Apr 16;10(4):614. doi: 10.3390/antiox10040614. PMID: 33923601

April 15

April 14

Reversible Nutritional Deficiency-Related Conjunctival Xerosis and Optic Neuropathy Secondary to an Exclusively Potato-Based Diet. Bailey MD, Mortensen PW, Raviskanthan S, Lee AG. J Neuroophthalmol. 2021 Apr 14. doi: 10.1097/WNO.0000000000001217. Online ahead of print. PMID: 33870939

April 13

A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress. Damal Villivalam S, Ebert SM, Lim HW, Kim J, You D, Jung BC, Palacios HH, Tcheau T, Adams CM, Kang S. EMBO J. 2021 Apr 13:e106491. doi: 10.15252/embj.2020106491. Online ahead of print. PMID: 33847380
Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Rheumatic Aortic Stenosis. Mentias A, Saad M, Desai MY, Krishnaswamy A, Menon V, Horwitz PA, Kapadia S, Sarrazin MV. J Am Coll Cardiol. 2021 Apr 13;77(14):1703-1713. doi: 10.1016/j.jacc.2021.02.032. PMID: 33832596

April 12

Counterpoint regarding an alternative hypothesis for why exposure to static magnetic and electric fields treat type 2 diabetes. Carter CS, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, Piorczynski TB, Pak TK, Walsh S, Acevedo M, Zhang Q, Mapuskar K, Milne G, Hinton AO Jr, Guo DF, Weiss RM, Bradberry K, Taylor EB, Rauckhorst A, Dick D, Akurathi V, Falls-Hubert K, Wagner B, Carter W, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00110.2021. Online ahead of print. PMID: 33843282
Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice. Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Sci Rep. 2021 Apr 12;11(1):7873. doi: 10.1038/s41598-021-87020-5. PMID: 33846453
Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Carter CS, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, Piorczynski TB, Pak TK, Walsh S, Acevedo M, Zhang Q, Mapuskar K, Milne G, Hinton AO Jr, Guo DF, Weiss RM, Bradberry K, Taylor EB, Rauckhorst A, Dick D, Akurathi V, Falls-Hubert K, Wagner B, Carter W, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. Am J Physiol Endocrinol Metab. 2021 Apr 12. doi: 10.1152/ajpendo.00119.2021. Online ahead of print. PMID: 33843283
Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice. Sun YJ, Velez G, Parsons DE, Li K, Ortiz ME, Sharma S, McCray PB Jr, Bassuk AG, Mahajan VB.J Clin Invest. 2021 Apr 12:147973. doi: 10.1172/JCI147973. Online ahead of print. PMID: 33844653

April 11

Meta Salud Diabetes for cardiovascular disease prevention in Mexico: a cluster-randomized behavioural clinical trial. Rosales CB, Denman CA, Bell ML, Cornejo E, Ingram M, Del Carmen Castro Vásquez M, Gonzalez-Fagoaga JE, Aceves B, Nuño T, Anderson EJ, Guernsey de Zapien J. Int J Epidemiol. 2021 Apr 11:dyab072. doi: 10.1093/ije/dyab072. Online ahead of print. PMID: 33842978

April 10

PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP. Kuburas A, Mason BN, Hing B, Wattiez AS, Reis AS, Sowers LP, Moldovan Loomis C, Garcia-Martinez LF, Russo AF. J Neurosci. 2021 Apr 10: JN-RM-2200-20. doi: 10.1523/JNEUROSCI.2200-20.2021. Online ahead of print. PMID: 33846231
Voices for Social Justice and Against Racism: An AAIM Perspective. Finn PW, Abel ED, Amin A, Anderson ME, Carethers JM, Coleman DL, Curtis AB, Geraci MW, Gladwin MT, Hollenberg A, Parmacek MS, Robbins RJ. Am J Med. 2021 Apr 10:S0002-9343(21)00219-9. doi: 10.1016/j.amjmed.2021.03.008. Online ahead of print. PMID: 33848502 No abstract available.

April 9

Adiposity and interstitial lung abnormalities in community dwelling adults: the MESA cohort study. Anderson MR, Kim JS, Allison M, Giles JT, Hoffman EA, Ding J, Barr RG, Podolanczuk A.Chest. 2021 Apr 9: S0012-3692(21)00675-9. doi: 10.1016/j.chest.2021.03.058. Online ahead of print. PMID: 33844978
Neurocognitive Features of Motor Premanifest Individuals With Myotonic Dystrophy Type 1. van der Plas E, Koscik TR, Magnotta V, Cumming SA, Monckton D, Gutmann L, Nopoulos P. Neurol Genet. 2021 Mar 18;7(2):e577. doi: 10.1212/NXG.0000000000000577. eCollection 2021 Apr. PMID: 33912661

April 8

The risk of preterm birth among women with a history of leukemia or lymphoma. Anand ST, Chrischilles EA, Baer RJ, Charlton ME, Breheny PJ, Terry WW, McLemore MR, Karasek DA, Jelliffe-Pawlowski LL, Ryckman KK.J Matern Fetal Neonatal Med. 2021 Apr 8:1-9. doi: 10.1080/14767058.2021.1907332. Online ahead of print.PMID: 33832388
Exponential increase in neutralizing and spike specific antibodies following vaccination of COVID-19 convalescent plasma donors. Vickers MA, Sariol A, Leon J, Ehlers A, Locher AV, Dubay KA, Collins L, Voss D, Odle AE, Holida M, Merrill AE, Perlman S, Knudson CM. Transfusion. 2021 Apr 8. doi: 10.1111/trf.16401. Online ahead of print. PMID: 33829513

April 7

Eggs, dietary cholesterol, choline, betaine, and diabetes risk in the Women's Health Initiative: a prospective analysis. Greenberg JA, Jiang X, Tinker LF, Snetselaar LG, Saquib N, Shadyab AH. Am J Clin Nutr. 2021 Apr 7:nqab036. doi: 10.1093/ajcn/nqab036. Online ahead of print. PMID: 33829251
Phenotypic and functional characteristics of a novel influenza hemagglutinin-specific memory NK cell. Zheng J, Wen L, Yen HL, Liu M, Liu Y, Teng O, Wu WF, Ni K, Lam KT, Huang C, Yang J, Lau YL, Perlman S, Peiris M, Tu W. J Virol. 2021 Apr 7:JVI.00165-21. doi: 10.1128/JVI.00165-21. Online ahead of print. PMID: 33827945
Practical Considerations for Implementation of SARS-CoV-2 Serological Testing in the Clinical Laboratory: Experience at an Academic Medical Center. Humble RM, Merrill AE, Ford BA, Diekema DJ, Krasowski MD. Acad Pathol. 2021 Apr 7;8:23742895211002802. doi: 10.1177/23742895211002802. eCollection 2021 Jan-Dec. PMID: 33889715 Free PMC article.
Prefusion F-Based Polyanhydride Nanovaccine Induces Both Humoral and Cell-Mediated Immunity Resulting in Long-Lasting Protection against Respiratory Syncytial Virus. Stephens LM, Ross KA, Waldstein KA, Legge KL, McLellan JS, Narasimhan B, Varga SM. J Immunol. 2021 Apr 7:ji2100018. doi: 10.4049/jimmunol.2100018. Online ahead of print. PMID: 33827894

April 6

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19. Doria-Rose N, Suthar MS, Makowski M, O'Connell S, McDermott AB, Flach B, Ledgerwood JE, Mascola JR, Graham BS, Lin BC, O'Dell S, Schmidt SD, Widge AT, Edara VV, Anderson EJ, Lai L, Floyd K, Rouphael NG, Zarnitsyna V, Roberts PC, Makhene M, Buchanan W, Luke CJ, Beigel JH, Jackson LA, Neuzil KM, Bennett H, Leav B, Albert J, Kunwar P; mRNA-1273 Study Group.N Engl J Med. 2021 Apr 6. doi: 10.1056/NEJMc2103916. Online ahead of print. PMID: 33822494 No abstract available.
A decision analytics model to optimize investment in interventions targeting the HIV PrEP cascade of care. Jenness SM, Knowlton G, Smith DK, Marcus JL, Anderson EJ, Siegler AJ, Jones J, Sullivan PS, Enns E. AIDS. 2021 Apr 6. doi: 10.1097/QAD.0000000000002909. Online ahead of print. PMID: 33831910
Dietary cholesterol and egg intake in relation to incident cardiovascular disease and all-cause and cause-specific mortality in postmenopausal women. Chen GC, Chen LH, Mossavar-Rahmani Y, Kamensky V, Shadyab AH, Haring B, Wild RA, Silver B, Kuller LH, Sun Y, Saquib N, Howard B, Snetselaar LG, Neuhouser ML, Allison MA, Van Horn L, Manson JE, Wassertheil-Smoller S, Qi Q. Am J Clin Nutr. 2021 Apr 6;113(4):948-959. doi: 10.1093/ajcn/nqaa353. PMID: 33330926
FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition. Reilly SM, Abu-Odeh M, Ameka M, DeLuca JH, Naber MC, Dadpey B, Ebadat N, Gomez AV, Peng X, Poirier B, Walk E, Potthoff MJ, Saltiel AR.J Clin Invest. 2021 Apr 6:145546. doi: 10.1172/JCI145546. Online ahead of print. PMID: 33822771

April 5

A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers. Romer SH, Metzger S, Peraza K, Wright MC, Jobe DS, Song LS, Rich MM, Foy BD, Talmadge RJ, Voss AA. J Gen Physiol. 2021 Apr 5; 153(4):e202012637. doi: 10.1085/jgp.202012637. PMID: 33683318
Cephalosporin antibiotics specifically and selectively target nasopharyngeal carcinoma through HMOX1-induced ferroptosis. He X, Yao Q, Fan D, Duan L, You Y, Liang W, Zhou Z, Teng S, Liang Z, Hall DD, Song LS, Chen B. Life Sci. 2021 Apr 5;277:119457. doi: 10.1016/j.lfs.2021.119457. Online ahead of print. PMID: 33831425

April 2

Knowledge of Sexual Transmission of Zika Virus Among Women Who Are Pregnant or Intend to Become Pregnant, Arizona, 2017. Anderson EJ, Ernst K, Garcia DO, Lopez E, Pogreba Brown K, Austhof E, Carr McCuin D, Hayden MH, Koss MP. Public Health Rep. 2021 Apr 2:333549211006986. doi: 10.1177/00333549211006986. Online ahead of print. PMID: 33798396

April 1

Association of Attention-Deficit/Hyperactivity Disorder With E-Cigarette Use. Xu G, Snetselaar LG, Strathearn L, Ryckman K, Nothwehr F, Torner J. Am J Prev Med. 2021 Apr; 60(4):488-496. doi: 10.1016/j.amepre.2020.11.010. PMID: 33745521
The NIH Somatic Cell Genome Editing program. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB Jr, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J; SCGE Consortium. Nature. 2021 Apr; 592(7853):195-204. doi: 10.1038/s41586-021-03191-1. Epub 2021 Apr 7. PMID: 33828315 Review.
Quantitative muscle MRI as a sensitive marker of early muscle pathology in myotonic dystrophy type 1. van der Plas E, Gutmann L, Thedens D, Shields RK, Langbehn K, Guo Z, Sonka M, Nopoulos P. Muscle Nerve. 2021 Apr;63(4):553-562. doi: 10.1002/mus.27174. Epub 2021 Feb 5. PMID: 33462896
Spatiotemporal clustering of in-hospital Clostridioides difficile infection. Pai S, Polgreen PM, Segre AM, Sewell DK, Pemmaraju SV; CDC MInD-Healthcare group. Infect Control Hosp Epidemiol. 2020 Apr;41(4):418-424. doi: 10.1017/ice.2019.350. Epub 2020 Jan 31. PMID: 32000873

May 31

Insulin Signaling In the Heart. Abel ED. Am J Physiol Endocrinol Metab. 2021 May 31. doi: 10.1152/ajpendo.00158.2021. Online ahead of print. PMID: 34056923

May 28

Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez FJ, Ozkan E, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC, Kesimer M. Lancet Respir Med. 2021 May 28:S2213-2600(21)00079-5. doi: 10.1016/S2213-2600(21)00079-5. Online ahead of print. PMID: 34058148
Homonymous hemianopsia as a reversible manifestation of normal-pressure hydrocephalus. Zehden J, Raviskanthan S, Bhat N, Mortensen P, Román GC, Lee AG. Can J Ophthalmol. 2021 May 28:S0008-4182(21)00159-9. doi: 10.1016/j.jcjo.2021.04.015. Online ahead of print. PMID: 34058141 No abstract available.

May 26

Case Series of Sphenoid Wing Meningioma - What is a Maximal Safe Resection? Seaman SC, Zanaty M, Crompton D, Piscopo A, Ankrah NK, Buatti JM, Greenlee JD, Howard MA. Neurochirurgie. 2021 May 26:S0028-3770(21)00153-3. doi: 10.1016/j.neuchi.2021.05.001. Online ahead of print. PMID: 34051247
Mitochondrial efflux of citrate and isocitrate is fully dispensable for glucose-stimulated insulin secretion and pancreatic islet β-cell function. Bauchle CJ, Rohli KE, Boyer CK, Pal V, Rocheleau JV, Liu S, Imai Y, Taylor EB, Stephens SB. Diabetes. 2021 May 26:db210037. doi: 10.2337/db21-0037. Online ahead of print. PMID: 34039628

May 24

Radiomic Based Machine Learning Performance for a Three Class Problem in Neuro-Oncology: Time to Test the Waters? Priya S, Liu Y, Ward C, Le NH, Soni N, Pillenahalli Maheshwarappa R, Monga V, Zhang H, Sonka M, Bathla G. Cancers (Basel). 2021 May 24;13(11):2568. doi: 10.3390/cancers13112568. PMID: 34073840

May 22

BMI modifies the association between dietary intake and serum levels of PCBs. Lan T, Liu B, Bao W, Thorne PS. Environ Int. 2021 May 22;156:106626. doi: 10.1016/j.envint.2021.106626. Online ahead of print. PMID: 34034117
Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche. Sarnowski C, Cousminer DL, Franceschini N, Raffield LM, Jia G, Fernández-Rhodes L, Grant SFA, Hakonarson H, Lange LA, Long J, Sofer T, Tao R, Wallace RB, Wong Q, Zirpoli G, Boerwinkle E, Bradfield JP, Correa A, Kooperberg CL, North KE, Palmer JR, Zemel BS, Zheng W, Murabito JM, Lunetta KL.Hum Reprod. 2021 May 22:deab086. doi: 10.1093/humrep/deab086. Online ahead of print. PMID: 34021356

May 21

Silencing Epidermal Growth Factor Receptor in Hypothalamic Paraventricular Nucleus Reduces Extracellular Signal-regulated Kinase 1 and 2 Signaling and Sympathetic Excitation in Heart Failure Rats. Yu Y, Wei SG, Weiss RM, Felder RB. Neuroscience. 2021 May 21;463:227-237. doi: 10.1016/j.neuroscience.2021.01.025. Epub 2021 Feb 2. PMID: 33540053

May 20

High-resolution vessel wall imaging after mechanical thrombectomy. Kasab SA, Bathla G, Varon A, Roa JA, Sabotin R, Raghuram A, Chaorong W, Hasan DM, Turan TN, Chatterjee R, Samaniego EA. Neuroradiol J. 2021 May 20:19714009211017782. doi: 10.1177/19714009211017782. Online ahead of print. PMID: 34014780
Impact of paravertebral blocks on analgesic and non-analgesic outcomes after video-assisted thoracoscopic surgery: A propensity matched cohort study. Ranganath YS, Ramanujam V, Onodera Y, Keech J, Arshava E, Parekh KR, Sondekoppam RV. PLoS One. 2021 May 20;16(5):e0252059. doi: 10.1371/journal.pone.0252059. eCollection 2021. PMID: 34015047

May 18

Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms. Sostre-Colón J, Uehara K, Garcia Whitlock AE, Gavin MJ, Ishibashi J, Potthoff MJ, Seale P, Titchenell PM. Cell Rep. 2021 May 18;35(7):109128. doi: 10.1016/j.celrep.2021.109128. PMID: 34010646
Low-fat dietary pattern and breast cancer mortality by metabolic syndrome components: a secondary analysis of the Women's Health Initiative (WHI) randomised trial. Pan K, Aragaki AK, Neuhouser ML, Simon MS, Luo J, Caan B, Snetselaar L, Mortimer JE, Manson JE, Kroenke C, Lane D, Reding K, Rohan TE, Chlebowski RT. Br J Cancer. 2021 May 18. doi: 10.1038/s41416-021-01379-w. Online ahead of print. PMID: 34006923
Machine learning based differentiation of glioblastoma from brain metastasis using MRI derived radiomics. Priya S, Liu Y, Ward C, Le NH, Soni N, Pillenahalli Maheshwarappa R, Monga V, Zhang H, Sonka M, Bathla G. Sci Rep. 2021 May 18;11(1):10478. doi: 10.1038/s41598-021-90032-w. PMID: 34006893
Patient perceptions and use of non-statin lipid lowering therapy among patients with or at risk for atherosclerotic cardiovascular disease: Insights from the PALM registry. Lowenstern A, Li S, Navar AM, Virani SS, Roger VL, Robinson JG, Goldberg AC, Kampman W, Peterson ED, Wang TY. Clin Cardiol. 2021 May 18. doi: 10.1002/clc.23625. Online ahead of print.PMID: 34008247

May 17

Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19. Lowery SA, Sariol A, Perlman S. Cell Host Microbe. 2021 May 17:S1931-3128(21)00232-8. doi: 10.1016/j.chom.2021.05.004. Online ahead of print. PMID: 34022154
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice. Sun YJ, Velez G, Parsons DE, Li K, Ortiz ME, Sharma S, McCray PB Jr, Bassuk AG, Mahajan VB. J Clin Invest. 2021 May 17;131(10):e147973. doi: 10.1172/JCI147973. PMID: 33844653

May 15

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. Jones WS, Mulder H, Wruck LM, Pencina MJ, Kripalani S, Muñoz D, Crenshaw DL, Effron MB, Re RN, Gupta K, Anderson RD, Pepine CJ, Handberg EM, Manning BR, Jain SK, Girotra S, Riley D, DeWalt DA, Whittle J, Goldberg YH, Roger VL, Hess R, Benziger CP, Farrehi P, Zhou L, Ford DE, Haynes K, VanWormer JJ, Knowlton KU, Kraschnewski JL, Polonsky TS, Fintel DJ, Ahmad FS, McClay JC, Campbell JR, Bell DS, Fonarow GC, Bradley SM, Paranjape A, Roe MT, Robertson HR, Curtis LH, Sharlow AG, Berdan LG, Hammill BG, Harris DF, Qualls LG, Marquis-Gravel G, Modrow MF, Marcus GM, Carton TW, Nauman E, Waitman LR, Kho AM, Shenkman EA, McTigue KM, Kaushal R, Masoudi FA, Antman EM, Davidson DR, Edgley K, Merritt JG, Brown LS, Zemon DN, McCormick TE 3rd, Alikhaani JD, Gregoire KC, Rothman RL, Harrington RA, Hernandez AF; ADAPTABLE Team. N Engl J Med. 2021 May 15. doi: 10.1056/NEJMoa2102137. Online ahead of print. PMID: 33999548
Test-based De-isolation in COVID-19 Immunocompromised patients: Ct value versus SARS-CoV-2 viral cultures. Alshukairi AN, Tolah AM, Dada A, Al-Tawfiq JA, Almagharbi RS, Saeedi MF, Al-Hamzi MA, El-Kafrawy SA, Bahaudden HA, El-Saeed A, Al-Mozaini MA, Khalid I, Hefni LK, Hassan AM, Alandijany TA, Bajrai LH, Bayumi DT, Albishi GE, Althawadi SI, Zabani NA, Perlman S, Azhar EI. Int J Infect Dis. 2021 May 15:S1201-9712(21)00429-X. doi: 10.1016/j.ijid.2021.05.027. Online ahead of print. PMID: 34004329

May 14

Cardiac Energy Metabolism in Heart Failure. Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. Circ Res. 2021 May 14;128(10):1487-1513. doi: 10.1161/CIRCRESAHA.121.318241. Epub 2021 May 13. PMID: 33983836
Characterization of performance and disinfection resilience of nonwoven filter materials for use in 3D-printed N95 respirators. O'Shaughnessy PT, Strzelecki B, Ortiz-Hernandez M, Aubin P, Jing X, Chang Q, Xiang J, Thorne PS, Stapleton JT. J Occup Environ Hyg. 2021 May 14:1-12. doi: 10.1080/15459624.2021.1913283. Online ahead of print. PMID: 33989113
Environmental endotoxin exposure and asthma JACI: Paradigms and Perspectives. Thorne PS. J Allergy Clin Immunol. 2021 May 14:S0091-6749(21)00735-1. doi: 10.1016/j.jaci.2021.05.004. Online ahead of print. PMID: 34000345 No abstract available.
Maternal microvascular dysfunction during preeclamptic pregnancy. Stanhewicz AE, Nuckols VR, Pierce GL. Clin Sci (Lond). 2021 May 14;135(9):1083-1101. doi: 10.1042/CS20200894. PMID: 33960392

May 13

Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis. Kaemmer CA, Umesalma S, Maharjan CK, Moose DL, Narla G, Mott SL, Zamba GKD, Breheny P, Darbro BW, Bellizzi AM, Henry MD, Quelle DE. Sci Rep. 2021 May 13;11(1):10252. doi: 10.1038/s41598-021-89866-1. PMID: 33986468 Free PMC article.

May 12

Albuminuria as a Predictor of Mortality from Chronic Lower Respiratory Disease and from Influenza and Pneumonia. Mendy A, Salo PM, Wilkerson J, Feinstein L, Fessler MB, Thorne PS, Zeldin DC. Ann Am Thorac Soc. 2021 May 12. doi: 10.1513/AnnalsATS.202009-1226RL. Online ahead of print. PMID: 33979561 No abstract available.
Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide. Sishc BJ, Ding L, Nam TK, Heer CD, Rodman SN, Schoenfeld JD, Fath MA, Saha D, Pulliam CF, Langen B, Beardsley RA, Riley DP, Keene JL, Spitz DR, Story MD. Sci Transl Med. 2021 May 12;13(593):eabb3768. doi: 10.1126/scitranslmed.abb3768. PMID: 33980575

May 11

Acute pancreatitis-induced islet dysfunction in ferrets. Yi Y, Sun X, Liang B, He N, Gibson-Corley KN, Norris AW, Engelhardt JF, Uc A. Pancreatology. 2021 May 11:S1424-3903(21)00147-2. doi: 10.1016/j.pan.2021.04.008. Online ahead of print. PMID: 33994067
D-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception. Gaston B, Baby SM, May WJ, Young AP, Grossfield A, Bates JN, Seckler JM, Wilson CG, Lewis SJ. Sci Rep. 2021 May 11;11(1):10038. doi: 10.1038/s41598-021-89455-2. PMID: 33976311
Measuring Multimorbidity: Selecting the Right Instrument for the Purpose and the Data Source. Suls J, Bayliss EA, Berry J, Bierman AS, Chrischilles EA, Farhat T, Fortin M, Koroukian SM, Quinones A, Silber JH, Ward BW, Wei M, Young-Hyman D, Klabunde CN. Med Care. 2021 May 11. doi: 10.1097/MLR.0000000000001566. Online ahead of print. PMID: 33974576

May 10

Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of COPD. Woo H, Brigham EP, Allbright K, Ejike C, Galiatsatos P, Jones MR, Oates GR, Krishnan JA, Cooper CB, Kanner RE, Bowler RP, Hoffman EA, Comellas AP, Criner G, Barr RG, Martinez FJ, Han MK, Ortega VE, Parekh TM, Christenson S, Belz D, Raju S, Gassett A, Paulin LM, Putcha N, Kaufman JD, Hansel NN. Am J Respir Crit Care Med. 2021 May 10. doi: 10.1164/rccm.202009-3721OC. Online ahead of print. PMID: 33971109

May 7

Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin. Sikdar S, Wyss AB, Lee MK, Hoang TT, Richards M, Beane Freeman LE, Parks C, Thorne PS, Hankinson JL, Umbach DM, Motsinger-Reif A, London SJ. Thorax. 2021 May 7:thoraxjnl-2020-215624. doi: 10.1136/thoraxjnl-2020-215624. Online ahead of print. PMID: 33963087

May 6

Case Studies in Physiology: Untangling the cause of hypoxemia in an obese patient with acute leukemia. Amaza I, Kalra H, Eberlein M, Jethava Y, McDonell J, Wolfe B, Tomasson MH, Bates ML. J Appl Physiol (1985). 2021 May 6. doi: 10.1152/japplphysiol.00867.2020. Online ahead of print. PMID: 33955261

May 5

COVID-19 Vaccines Have Moved Out of Neutral, but Still Gearing Up in Children. Anderson EJ, Kamidani S, Orenstein W, Campbell JD. Clin Infect Dis. 2021 May 5 :ciab400. doi: 10.1093/cid/ciab400. Online ahead of print. PMID: 33949653
Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain. Mantus G, Nyhoff LE, Kauffman RC, Edara VV, Lai L, Floyd K, Shi PY, Menachery VD, Edupuganti S, Scherer EM, Kay A, McNair N, Anderson EJ, Rouphael N, Ahmed R, Suthar MS, Wrammert J. J Immunol. 2021 May 5: ji2001420. doi: 10.4049/jimmunol.2001420. Online ahead of print. PMID: 33952616
Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction. EPI Study Group, Hage CA, Klesney-Tait J, Wille K, Arcasoy S, Yung G, Hertz M, Chan KM, Morrell M, Goldberg H, Vedantham S, Derfler MC, Commean P, Berman K, Spitznagel E, Atkinson J, Despotis G. Transfus Med. 2021 May 5. doi: 10.1111/tme.12779. Online ahead of print. PMID: 33955079
Scoliosis in Friedreich's ataxia: longitudinal characterization in a large heterogeneous cohort. Rummey C, Flynn JM, Corben LA, Delatycki MB, Wilmot G, Subramony SH, Bushara K, Duquette A, Gomez CM, Hoyle JC, Roxburgh R, Seeberger L, Yoon G, Mathews KD, Zesiewicz T, Perlman S, Lynch DR. Ann Clin Transl Neurol. 2021 May 5. doi: 10.1002/acn3.51352. Online ahead of print. PMID: 33949801

May 4

OPA1 deletion in brown adipose tissue Improves thermoregulation and systemic metabolism via FGF21. Pereira RO, Marti A, Olvera AC, Tadinada SM, Bjorkman SH, Weatherford ET, Morgan DA, Westphal M, Patel PH, Kirby AK, Hewezi R, Bùi Trần W, García-Peña LM, Souvenir RA, Mittal M, Adams CM, Rahmouni K, Potthoff MJ, Abel ED. Elife. 2021 May 4;10:e66519. doi: 10.7554/eLife.66519. Online ahead of print. PMID: 33944779

May 3

Association between serum selenium concentrations and learning disability in a nationally representative sample of U.S. children. Liu B, Xu G, Yang W, Strathearn L, Snetselaar LG, Bao W. Nutr Neurosci. 2021 May 3:1-7. doi: 10.1080/1028415X.2021.1879541. Online ahead of print. PMID: 33939947
Cardiovascular disease (CVD) risk scores, age, or years since menopause to predict cardiovascular disease in the Women's Health Initiative. Wild RA, Hovey KM, Andrews C, Robinson JG, Kaunitz AM, Manson JE, Crandall CJ, Paragallo R, Shufelt C, Merz CNB. Menopause. 2021 May 3. doi: 10.1097/GME.0000000000001753. Online ahead of print. PMID: 33950030
Discontinuation of Isolation Precautions for COVID-19 Patients. Anderson L, Schmitz E, Polgreen PM, Beekmann SE, Safdar N. Infect Control Hosp Epidemiol. 2021 May 3:1-9. doi: 10.1017/ice.2021.188. Online ahead of print. PMID: 33934740
Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience. Santillan MK, Becker RC, Calhoun DA, Cowley AW, Flynn JT, Grobe JL, Kotchen TA, Lackland DT, Leslie KK, Liang M, Mattson DL, Meyers KE, Mitsnefes MM, Muntner PM, Pierce GL, Pollock JS, Sigmund CD, Thomas SJ, Urbina EM, Kidambi S. Hypertension. 2021 May 3: HYPERTENSIONAHA12016296. doi:10.1161/HYPERTENSIONAHA.120.16296 PMID: 33934625

May 2

Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508-CFTR for cystic fibrosis. Hodos RA, Strub MD, Ramachandran S, Meleshkevitch EA, Boudko DY, Bridges RJ, Dudley JT, McCray PB Jr. CPT Pharmacometrics Syst Pharmacol. 2021 May 2. doi: 10.1002/psp4.12626. Online ahead of print. PMID: 33934548
Regional Gas Transport During Conventional and Oscillatory Ventilation Assessed by Xenon-Enhanced Computed Tomography. Herrmann J, Gerard SE, Reinhardt JM, Hoffman EA, Kaczka DW. Ann Biomed Eng. 2021 May 4. doi: 10.1007/s10439-021-02767-2. Online ahead of print. PMID: 33948747

May 1

Impact of Telehealth Interventions on Medication Adherence for Patients With Type 2 Diabetes, Hypertension, and/or Dyslipidemia: A Systematic Review. Bingham JM, Black M, Anderson EJ, Li Y, Toselli N, Fox S, Martin JR, Axon DR, Silva-Almodóvar A.Ann Pharmacother. 2021 May;55(5):637-649. doi: 10.1177/1060028020950726. Epub 2020 Aug 20. PMID: 32815400
Lef-1 controls cell cycle progression in airway basal cells to regulate proliferation and differentiation. Jensen-Cody CW, Crooke AK, Rotti PG, Ievlev V, Shahin W, Park SY, Lynch TJ, Engelhardt JF. Stem Cells. 2021 May 1. doi: 10.1002/stem.3386. Online ahead of print. PMID: 33932322
Occupations Associated With Poor Cardiovascular Health in Women: The Women's Health Initiative Observational Study. Nriagu BN, Ako AA, Wang C, De Roos AJ, Wallace R, Allison MA, Seguin RA, Michael YL. J Occup Environ Med. 2021 May 1;63(5):387-394. doi: 10.1097/JOM.0000000000002135. PMID: 33928936
Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy. Wenker IC, Teran FA, Wengert ER, Wagley PK, Panchal PS, Blizzard EA, Saraf P, Wagnon JL, Goodkin HP, Meisler MH, Richerson GB, Patel MK. Ann Neurol. 2021 May;89(5):1023-1035. doi: 10.1002/ana.26053. Epub 2021 Mar 6. PMID: 33604927
Why Truthfulness is the First of the Virtues. Kaldjian LC, Pilkington BC. Am J Bioeth. 2021 May ;21(5):36-38. doi: 10.1080/15265161.2021.1906991. PMID: 33945424

June 30

A Pilot Study of Preoperative Vandetanib on Markers of Proliferation and Apoptosis in Breast Cancer. Spanheimer PM, Bashir A, Lorenzen AW, Beck AC, Liao J, Lizarraga IM, Erdahl LM, Sugg SL, Karwal MW, Weigel RJ. Am J Clin Oncol. 2021 Jun 30. doi: 10.1097/COC.0000000000000845. Online ahead of print. PMID: 34190716
CGRP induces migraine-like symptoms in mice during both the active and inactive phases. Wattiez AS, Gaul OJ, Kuburas A, Zorilla E, Waite JS, Mason BN, Castonguay WC, Wang M, Robertson BR, Russo AF. J Headache Pain. 2021 Jun 30;22(1):62. doi: 10.1186/s10194-021-01277-9. PMID: 34193048
Four evolving concepts in molecular and clinical autonomic research. Abboud FM. Clin Auton Res. 2021 Jun 30. doi: 10.1007/s10286-021-00816-3. Online ahead of print. PMID: 34191210.
Polycythemia is Associated with Lower Incidence of Severe COPD Exacerbations in SPIROMICS Study. Fawzy A, Woo H, Balasubramanian A, Barjaktarevic I, Barr RG, Bowler RP, Comellas AP, Cooper CB, Couper D, Criner GJ, Dransfield MT, Han MK, Hoffman EA, Kanner RE, Krishnan JA, Martinez FJ, McCormack M, Paine Iii R, Peters S, Wise R, Woodruff PG, Hansel NN, Putcha N. Chronic Obstr Pulm Dis. 2021 Jun 30. doi: 10.15326/jcopdf.2021.0216. Online ahead of print. PMID: 34197703
Vascular Effects of Disrupting Endothelial mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Obesity. Reho JJ, Guo DF, Beyer AM, Wegman-Points L, Pierce GL, Rahmouni K. Am J Physiol Regul Integr Comp Physiol. 2021 Jun 30. doi: 10.1152/ajpregu.00113.2021. Online ahead of print. PMID: 34189960

June 29

Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Gitelman SE, Bundy BN, Ferrannini E, Lim N, Blanchfield JL, DiMeglio LA, Felner EI, Gaglia JL, Gottlieb PA, Long SA, Mari A, Mirmira RG, Raskin P, Sanda S, Tsalikian E, Wentworth JM, Willi SM, Krischer JP, Bluestone JA; Gleevec Trial Study Group. Lancet Diabetes Endocrinol. 2021 Jun 29:S2213-8587(21)00139-X. doi: 10.1016/S2213-8587(21)00139-X. Online ahead of print. PMID: 34214479

June 28

Adherence to Recommended Eating Patterns Is Associated With Lower Risk of Peripheral Arterial Disease: Results From the Women's Health Initiative. Chen GC, Arthur R, Mossavar-Rahmani Y, Xue X, Haring B, Shadyab AH, Allison MA, Liu S, Tinker LF, Saquib N, Coday M, Shikany JM, Neuhouser ML, Snetselaar LG, Van Horn L, Rohan TE, Wassertheil-Smoller S, Kaplan RC, Qi Q. Hypertension. 2021 Jun 28:HYPERTENSIONAHA12117432. doi: 10.1161/HYPERTENSIONAHA.121.17432. Online ahead of print. PMID: 34176290
Outcomes of peroral endoscopic myotomy in patients with achalasia and prior bariatric surgery: A multicenter experience. Bomman S, Klair JS, Ashat M, El Abiad R, Gerke H, Keech J, Parekh K, Nau P, Hanada Y, Wong Kee Song LM, Kozarek R, Irani S, Low D, Ross A, Krishnamoorthi R. Dis Esophagus. 2021 Jun 28:doab044. doi: 10.1093/dote/doab044. Online ahead of print. PMID: 34184036

June 26

Exome-based investigation of the genetic basis of human pigmentary glaucoma. van der Heide C, Goar W, Meyer KJ, Alward WLM, Boese EA, Sears NC, Roos BR, Kwon YH, DeLuca AP, Siggs OM, Gonzaga-Jauregui C, Sheffield VC, Wang K, Stone EM, Mullins RF, Anderson MG, Fan BJ, Ritch R, Craig JE, Wiggs JL, Scheetz TE, Fingert JH. BMC Genomics. 2021 Jun 26;22(1):477. doi: 10.1186/s12864-021-07782-0.PMID: 34174832.

June 25

Early Lung Disease Exhibits Bacterial-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs. Bouzek DC, Abou Alaiwa MH, Adam RJ, Pezzulo AA, Reznikov LR, Cook DP, Aguilar Pescozo MI, Ten Eyck P, Wu C, Gross TJ, Hornick DB, Hoffman EA, Meyerholz DK, Stoltz DA. Am J Respir Crit Care Med. 2021 Jun 25. doi: 10.1164/rccm.202102-0451OC. Online ahead of print. PMID: 34170795

June 24

Case Studies in Physiology: Temporal Variations of the Lung Parenchyma and Vasculature in Asymptomatic COVID-19 Pneumonia: A Multi-Spectral CT Assessment. Nagpal P, Motahari A, Gerard SE, Guo J, Reinhardt JM, Comellas AP, Hoffman EA, Kaczka DW. J Appl Physiol (1985). 2021 Jun 24. doi: 10.1152/japplphysiol.00147.2021. Online ahead of print. PMID: 34166081
COVID-19 Admission Screening, and Assessment of Infectiousness at an Academic Medical Center, Iowa 2020. Alsuhaibani M, Kobayashi T, Trannel A, Holley S, Abosi OJ, Jenn KE, Meacham H, Sheeler L, Etienne W, Dains A, Kukla ME, Ward E, Ford B, Edmond MB, Wellington M, Diekema DJ, Salinas JL. Infect Control Hosp Epidemiol. 2021 Jun 24:1-19. doi: 10.1017/ice.2021.294. Online ahead of print. PMID: 34169812
Inflammatory cytokines TNFα and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators. Rehman T, Karp PH, Tan P, Goodell BJ, Pezzulo AA, Thurman AL, Thornell IM, Durfey SL, Duffey ME, Stoltz DA, McKone EF, Singh PK, Welsh MJ. J Clin Invest. 2021 Jun 24:150398. doi: 10.1172/JCI150398. Online ahead of print. PMID: 34166230
Molecular epidemiology of large coronavirus disease 2019 (COVID-19) clusters before and after the implementation of routine serial testing at an academic medical center in Iowa, 2020. Ortiz ME, Kobayashi T, Imborek K, Alsuhaibani M, Holley S, Trannel A, Marra AR, Etienne W, Jenn KE, Abosi OJ, Meacham H, Sheeler L, Dains A, Kukla ME, McCray PB, Perlman S, Ford B, Diekema DJ, Wellington M, Pezzulo AA, Salinas JL.Infect Control Hosp Epidemiol. 2021 Jun 24:1-3. doi: 10.1017/ice.2021.301. Online ahead of print. PMID: 34229775

June 23

Radiation-induced Hounsfield unit change correlates with dynamic CT perfusion better than 4DCT-based ventilation measures in a novel-swine model. Wuschner AE, Wallat EM, Flakus MJ, Shanmuganayagam D, Meudt J, Christensen GE, Reinhardt JM, Miller JR, Lawless MJ, Baschnagel AM, Bayouth JE. Sci Rep. 2021 Jun 23;11(1):13156. doi: 10.1038/s41598-021-92609-x. PMID: 34162987

June 19

A "Failed" Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage. Wen KK, Roy S, Grumbach IM, Wu M. SLAS Discov. 2021 Jun 19:24725552211020678. doi: 10.1177/24725552211020678. Online ahead of print. PMID: 34151632
Automated Segmentation of Choroidal Layers from 3-Dimensional Macular Optical Coherence Tomography Scans. Lee K, Warren AK, Abràmoff MD, Wahle A, Whitmore SS, Han IC, Fingert JH, Scheetz TE, Mullins RF, Sonka M, Sohn EH. J Neurosci Methods. 2021 Jun 19:109267. doi: 10.1016/j.jneumeth.2021.109267. Online ahead of print. PMID: 34157370

June 18

Characterization of performance and disinfection resilience of nonwoven filter materials for use in 3D-printed N95 respirators. O'Shaughnessy PT, Strzelecki B, Ortiz-Hernandez M, Aubin P, Jing X, Chang Q, Xiang J, Thorne PS, Stapleton JT. J Occup Environ Hyg. 2021 Jun;18(6):265-275. doi: 10.1080/15459624.2021.1913283. Epub 2021 May 14. PMID: 33989113
Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche. Sarnowski C, Cousminer DL, Franceschini N, Raffield LM, Jia G, Fernández-Rhodes L, Grant SFA, Hakonarson H, Lange LA, Long J, Sofer T, Tao R, Wallace RB, Wong Q, Zirpoli G, Boerwinkle E, Bradfield JP, Correa A, Kooperberg CL, North KE, Palmer JR, Zemel BS, Zheng W, Murabito JM, Lunetta KL. Hum Reprod. 2021 Jun 18;36(7):1999-2010. doi: 10.1093/humrep/deab086. PMID: 34021356
Prolonged Reactive Oxygen Species Production following Septic Insult. Jensen IJ, McGonagill PW, Berton RR, Wagner BA, Silva EE, Buettner GR, Griffith TS, Badovinac VP. Immunohorizons. 2021 Jun 18;5(6):477-488. doi:10.4049/immunohorizons.2100027. PMID: 34145054
TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling. Arkee T, Hostager BS, Houtman JCD, Bishop GA. J Immunol. 2021 Jun 18:ji2001220. doi: 10.4049/jimmunol.2001220. Online ahead of print. PMID: 34145060

June 16

Radiomics side experiments and DAFIT approach in identifying pulmonary hypertension using Cardiac MRI derived radiomics based machine learning models. Priya S, Aggarwal T, Ward C, Bathla G, Jacob M, Gerke A, Hoffman EA, Nagpal P. Sci Rep. 2021 Jun 16;11(1):12686. doi: 10.1038/s41598-021-92155-6. PMID: 34135418 Free PMC article.
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Sci Adv. 2021 Jun 16;7(25):eabf8577. doi: 10.1126/sciadv.abf8577. Print 2021 Jun. PMID: 34134991

June 15

Middle East respiratory syndrome coronavirus Spike protein variants exhibit geographic differences in virulence. Wong LR, Zheng J, Sariol A, Lowery S, Meyerholz DK, Gallagher T, Perlman S. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2102983118. doi: 10.1073/pnas.2102983118. PMID: 34099556

June 10

Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction. De Silva TM, Modrick ML, Grobe JL, Faraci FM. Stroke. 2021 Jun 10:STROKEAHA121034984. doi: 10.1161/STROKEAHA.121.034984. Online ahead of print. PMID: 34107734

June 8

SARS-CoV-2 takes its Toll. Sariol A, Perlman S. Nat Immunol. 2021 Jun 8. doi: 10.1038/s41590-021-00962-w. Online ahead of print. PMID: 34103714.

June 7

Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Akintoye E, Afonso L, Bengaluru Jayanna M, Bao W, Briasoulis A, Robinson J. J Am Heart Assoc. 2021 Jun 7:e019589. doi: 10.1161/JAHA.120.019589. Online ahead of print. PMID: 34092110

June 4

Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega MA. Science. 2021 Jun 4;372(6546):1085-1091. doi: 10.1126/science.abf1008. PMID: 34083488.
Ketogenic Diet with Concurrent Chemoradiation in Head and Neck Squamous Cell Carcinoma: Preclinical and Phase 1 Trial Results. Ma DC, Anderson CM, Rodman SN, Buranasudja V, McCormick ML, Davis A, Loth E, Bodeker KL, Ahmann L, Parkhurst JR, Sun W, Follmer KR, Simons AL, Buatt JM, Spitz DR, Fath MA, Allen BG. Radiat Res. 2021 Jun 4. doi: 10.1667/RADE-20-00150.1. Online ahead of print. PMID: 34087943.

June 3

Axonopathy precedes cell death in ocular damage mediated by blast exposure. Boehme NA, Hedberg-Buenz A, Tatro N, Bielecki M, Castonguay WC, Scheetz TE, Anderson MG, Dutca LM. Sci Rep. 2021 Jun 3;11(1):11774. doi: 10.1038/s41598-021-90412-2. PMID: 34083587.

June 2

Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor. Blumenfeld A, Durham PL, Feoktistov A, Hay DL, Russo AF, Turner I. Neurol Ther. 2021 Jun 2. doi: 10.1007/s40120-021-00250-7. Online ahead of print.PMID: 34076848.

June 1

Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D. Zheng J, Meyerholz D, Wong LR, Gelb M, Murakami M, Perlman S. J Clin Invest. 2021 Jun 1;131(11):147201. doi: 10.1172/JCI147201. PMID: 34060490.
In reply-COVID-19: Precision Medicine and Vascular Endothelium. Cresci S, Ahmad F, Pereira NL. Mayo Clin Proc. 2021 Jun;96(6):1672. doi: 10.1016/j.mayocp.2021.04.006. Epub 2021 Apr 19. PMID: 34088425 Free PMC article.
The potential role of MR-guided adaptive radiotherapy in pediatric oncology: Results from a SIOPE-COG survey. Seravalli E, Kroon PS, Buatti JM, Hall MD, Mandeville HC, Marcus KJ, Onal C, Ozyar E, Paulino AC, Paulsen F, Saunders D, Tsang DS, Wolden SL, Janssens GO. Clin Transl Radiat Oncol. 2021 Jun 4;29:71-78. doi: 10.1016/j.ctro.2021.05.008. eCollection 2021 Jul. PMID: 34159265 Free PMC article.
The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent. Harper MM, Boehme N, Dutca LM, Anderson MG.Invest Ophthalmol Vis Sci. 2021 Jun 1;62(7):13. doi: 10.1167/iovs.62.7.13. PMID: 34106210.
Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy. Petronek MS, Stolwijk JM, Murray SD, Steinbach EJ, Zakharia Y, Buettner GR, Spitz DR, Allen BG. Redox Biol. 2021 Jun;42:101864.doi: 10.1016/j.redox.2021.101864. Epub 2021 Jan 16. PMID: 33485837 Free PMC article. Review.

July 31

Association of Coronavirus Disease-19 Hospitalization Volume and Case Growth at United States Hospitals with Patient Outcomes. Khera R, Liu Y, de Lemos JA, Das SR, Pandey A, Omar W, Kumbhani DJ, Girotra S, Yeh RW, Rutan C, Walcoch J, Lin Z, Bradley SM, Velazquez EJ, Churchwell KB, Nallamothu BK, Krumholz HM, Curtis JP. Am J Med. 2021 Jul 31:S0002-9343(21)00468-X. doi: 10.1016/j.amjmed.2021.06.034. Online ahead of print. PMID: 34343515

July 30

Post-viral effects of COVID-19 in the olfactory system and their implications. Xydakis MS, Albers MW, Holbrook EH, Lyon DM, Shih RY, Frasnelli JA, Pagenstecher A, Kupke A, Enquist LW, Perlman S. Lancet Neurol. 2021 Jul 30:S1474-4422(21)00182-4. doi: 10.1016/S1474-4422(21)00182-4. Online ahead of print. PMID: 34339626

July 28

Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 non-structural protein 9. Littler DR, Mohanty B, Lowery SA, Colson RN, Gully BS, Perlman S, Scanlon MJ, Rossjohn J. J Biol Chem. 2021 Jul 28:101018. doi: 10.1016/j.jbc.2021.101018. Online ahead of print. PMID: 34331944
Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans. Schlievert PM, Roller RJ, Kilgore SH, Villarreal M, Klingelhutz AJ, Leung DYM.mSphere. 2021 Jul 28:e0060821. doi: 10.1128/mSphere.00608-21. Online ahead of print.PMID: 34319127
Traumatic brain injury and sight loss in military and veteran populations- a review. Hussain SF, Raza Z, Cash ATG, Zampieri T, Mazzoli RA, Kardon RH, Gomes RSM. Mil Med Res. 2021 Jul 28;8(1):42. doi: 10.1186/s40779-021-00334-3. PMID: 34315537 Review.

July 27

An Unusual Presentation of CLN3-Associated Batten Disease With Classic Histopathologic and Ultrastructural Findings. Evans LP, Gibson-Corley KN, Mullins RF, Tucker BA, Trent A, Stone EM, Jones KA. J Neuropathol Exp Neurol. 2021 Jul 27:nlab064. doi: 10.1093/jnen/nlab064. Online ahead of print. PMID: 34313756

July 26

Thrombotic potential during pediatric acute lymphoblastic leukemia induction: Role of cell-free DNA. Kumar R, Katare PB, Lentz SR, Modi AJ, Sharathkumar AA, Dayal S. Res Pract Thromb Haemost. 2021 Jul 26;5(5):e12557. doi: 10.1002/rth2.12557. eCollection 2021 Jul. PMID: 34337307

July 22

Endothelial BBSome is Essential for Vascular, Metabolic, and Retinal Functions. Jiang J, Reho JJ, Bhattarai S, Cherascu I, Hedberg-Buenz A, Meyer KJ, Tayyari F, Rauckhorst AJ, Guo DF, Morgan DA, Taylor EB, Anderson MG, Drack AV, Rahmouni K. Mol Metab. 2021 Jul 22:101308. doi: 10.1016/j.molmet.2021.101308. Online ahead of print. PMID: 34303879
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease. Dampalla CS, Kim Y, Bickmeier N, Rathnayake AD, Nguyen HN, Zheng J, Kashipathy MM, Baird MA, Battaile KP, Lovell S, Perlman S, Chang KO, Groutas WC. J Med Chem. 2021 Jul 22;64(14):10047-10058. doi: 10.1021/acs.jmedchem.1c00319. Epub 2021 Jul 2. PMID: 34213885

July 21

CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects. Kang JH, Choi J, Chae KJ, Shin KM, Lee CH, Guo J, Lin CL, Hoffman EA, Lee C.Sci Rep. 2021 Jul 21;11(1):14923. doi: 10.1038/s41598-021-93980-5. PMID: 34290275
Inter-subject variation in ACE2 protein expression in human airway epithelia and its relationship to SARS-CoV-2 infection. Li K, Wohlford-Lenane C, Bartlett JA, McCray PB. J Infect Dis. 2021 Jul 21:jiab383. doi: 10.1093/infdis/jiab383. Online ahead of print. PMID: 34289058
Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV): Long-Term Outcomes and Risk Factors for Vision Loss in ADNIV. Boyce TM, Scott Whitmore S, Varzavand K, Russell SR, Sohn EH, Folk JC, Stone EM, Han IC. Am J Ophthalmol. 2021 Jul 21:S0002-9394(21)00382-2. doi: 10.1016/j.ajo.2021.07.015. Online ahead of print. PMID: 34302771

July 20

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Dampalla CS, Zheng J, Perera KD, Wong LR, Meyerholz DK, Nguyen HN, Kashipathy MM, Battaile KP, Lovell S, Kim Y, Perlman S, Groutas WC, Chang KO. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2101555118. doi: 10.1073/pnas.2101555118. PMID: 34210738

July 19

24-Hour Blood Pressure Variability is Associated with Lower Cognitive Performance in Young Women with a Recent History of Preeclampsia. Nuckols VR, Stroud AK, Hueser JF, Brandt DS, DuBose LE, Santillan DA, Santillan MK, Pierce GL. Am J Hypertens. 2021 Jul 19:hpab112. doi: 10.1093/ajh/hpab112. Online ahead of print. PMID: 34278420
Effectiveness of portable HEPA air cleaners on reducing indoor endotoxin, PM_10, and coarse particulate matter in an agricultural cohort of children with asthma: A randomized intervention trial. Riederer AM, Krenz JE, Tchong-French MI, Torres E, Perez A, Younglove LR, Jansen KL, Hardie DC, Farquhar SA, Sampson PD, Metwali N, Thorne PS, Karr CJ. Indoor Air. 2021 Jul 19. doi: 10.1111/ina.12858. Online ahead of print. PMID: 34288127
Reviewing Peer Review. London B. J Am Heart Assoc. 2021 Jul 19:e021475. doi: 10.1161/JAHA.121.021475. Online ahead of print. PMID: 34278832

July 18

Influence of endocrine multidisciplinary tumor board on patient management and treatment decision making. Kelley S, Beck AC, Weigel RJ, Howe JR, Sugg SL, Lal G.Am J Surg. 2021 Jul 18:S0002-9610(21)00393-7. doi: 10.1016/j.amjsurg.2021.07.013. Online ahead of print. PMID: 3430352

July 17

Associations between neurofilament light-chain protein, brain structure, and chronic kidney disease. van der Plas E, Lullmann O, Hopkins L, Schultz JL, Nopoulos PC, Harshman LA. Pediatr Res. 2021 Jul 17. doi: 10.1038/s41390-021-01649-6. Online ahead of print. PMID: 34274959

July 16

Metastatic renal cell carcinoma to the spine: outcomes and morbidity. Single center experience. Park BJ, Seaman SC, Noeller JL, Smith MC, Hasan DM, Yasin H, Hitchon PW. World Neurosurg. 2021 Jul 16:S1878-8750(21)01036-6. doi: 10.1016/j.wneu.2021.07.041. Online ahead of print. PMID: 34280537
Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage. Stolwijk JM, Stefely JA, Veling MT, van 't Erve TJ, Wagner BA, Raife TJ, Buettner GR. Redox Biol. 2021 Jul 16;46:102073. doi: 10.1016/j.redox.2021.102073. Online ahead of print. PMID: 34298465
Sugar-sweetened Beverage Consumption May Modify Associations between Genetic Variants in the CHREBP Locus and HDL-C and TG Concentrations. Haslam DE, Peloso GM, Guirette M, Imamura F, Bartz TM, Pitsillides AN, Wang CA, Li-Gao R, Westra JM, Pitkänen N, Young KL, Graff M, Wood AC, Braun KVE, Luan J, Kähönen M, Kiefte-de Jong JC, Ghanbari M, Tintle N, Lemaitre RN, Mook-Kanamori DO, North K, Helminen M, Mossavar-Rahmani Y, Snetselaar L, Martin LW, Viikari JS, Oddy WH, Pennell CE, Rosendaal FR, Ikram MA, Uitterlinden AG, Psaty BM, Mozaffarian D, Rotter JI, Taylor KD, Lehtimäki T, Raitakari OT, Livingston KA, Voortman T, Forouhi NG, Wareham NJ, de Mutsert R, Rich SS, Manson JE, Mora S, Ridker PM, Merino J, Meigs JB, Dashti HS, Chasman DI, Lichtenstein AH, Smith CE, Dupuis J, Herman MA, McKeown NM. Circ Genom Precis Med. 2021 Jul 16. doi: 10.1161/CIRCGEN.120.003288. Online ahead of print. PMID: 34270325

July 15

Gastric Bypass Sensitizes Sympathetic and Thermogenic Activity of Brown Adipose Tissue to Cold Exposure. Chu Y, Tian L, Herz H, Linden B, Morgan DA, Naber MC, Potthoff M, Rahmouni K, Mokadem M. Obes Surg. 2021 Jul 15. doi: 10.1007/s11695-021-05560-1. Online ahead of print. PMID: 34264434
Hypercapnic ventilatory response in epilepsy patients treated with VNS: A case-control study. Sainju RK, Dragon DN, Winnike HB, Ten Eyck P, Granner MA, Gehlbach BK, Richerson GB. Epilepsia. 2021 Jul 15. doi: 10.1111/epi.16997. Online ahead of print. PMID: 34265074

July 12

COVID-19 Incidence After Exposures in Shared Patient Rooms, Tertiary Care Center, Iowa, July 2020-May 2021. Trannel A, Kobayashi T, Dains A, Abosi OJ, Jenn KE, Meacham H, Sheeler LL, Etienne W, Kukla ME, Alsuhaibani M, Holley S, Strandberg K, Marra AR, Kritzman J, Ford B, Wellington M, Diekema DJ, Salinas JL.Infect Control Hosp Epidemiol. 2021 Jul 12:1-13. doi: 10.1017/ice.2021.313. Online ahead of print. PMID: 34250882
Surgical Decision-Making Surrounding Contralateral Prophylactic Mastectomy: Comparison of Treatment Goals, Preferences, and Psychosocial Outcomes from a Multicenter Survey of Breast Cancer Patients. Lizarraga IM, Schroeder MC, Jatoi I, Sugg SL, Trentham-Dietz A, Hoeth L, Chrischilles EA. Ann Surg Oncol. 2021 Jul 12. doi: 10.1245/s10434-021-10426-y. Online ahead of print. PMID: 34251554

July 10

The influence of social support on cognitive health in older women: a Women's Health Initiative study. Moreno GL, Ammann E, Kaseda ET, Espeland MA, Wallace R, Robinson J, Denburg NL. J Women Aging. 2021 Jul 10:1-17. doi: 10.1080/08952841.2021.1945368. Online ahead of print. PMID: 34252006

July 9

Aneurysm Wall Enhancement Is Associated With Decreased Intrasaccular IL-10 and Morphological Features of Instability. Swiatek VM, Neyazi B, Roa JA, Zanaty M, Samaniego EA, Ishii D, Lu Y, Sandalcioglu IE, Saalfeld S, Berg P, Hasan DM. Neurosurgery. 2021 Jul 9:nyab249. doi: 10.1093/neuros/nyab249. Online ahead of print. PMID: 34245147

July 8

COVID-19 modeling and non-pharmaceutical interventions in an outpatient dialysis unit. Jang H, Polgreen PM, Segre AM, Pemmaraju SV. PLoS Comput Biol. 2021 Jul 8; 17(7):e1009177. doi: 10.1371/journal.pcbi.1009177. Online ahead of print. PMID: 34237062
Standard prophylactic versus intermediate dose enoxaparin in adults with severe COVID-19: a multi-center, open-label, randomized controlled trial: zed controlled trial. Perepu US, Chambers I, Wahab A, Ten Eyck P, Wu C, Dayal S, Sutamtewagul G, Bailey SR, Rosenstein LJ, Lentz SR. J Thromb Haemost. 2021 Jul 8. doi: 10.1111/jth.15450. Online ahead of print. PMID: 34236768

July 6

Aneurysmal Subarachnoid Hemorrhage in COVID-19 Patients: A Case Series. Dodd WS, Jabbour PM, Sweid A, Tjoumakaris S, Gooch MR, Al Saiegh F, Hasan DM, Starke RM, Kan PT, Polifka AJ, Laurent D, Busl KM, Ghosh R, Hoh BL, Chalouhi N. World Neurosurg. 2021 Jul 6:S1878-8750(21)00933-5. doi: 10.1016/j.wneu.2021.06.092. Online ahead of print. PMID: 34242830

July 5

MRSA Strains with Distinct Accessory Genes Predominate at Different Ages in Cystic Fibrosis. Porterfield HS, Maakestad LJ, LaMarche MM, Thurman AL, Kienenberger ZE, Pitcher NJ, Hansen AR, Zirbes CF, Boyken L, Muyskens BL, Pezzulo AA, Singh SB, Twait E, Ford B, Diekema DJ, Reeb V, Fischer AJ. Pediatr Pulmonol. 2021 Jul 5. doi: 10.1002/ppul.25559. Online ahead of print. PMID: 34219414
Science, not speculation, is essential to determine how SARS-CoV-2 reached humans.Calisher CH, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya AE, Haagmans B, Hughes JM, Keusch GT, Lam SK, Lubroth J, Mackenzie JS, Madoff L, Mazet JK, Perlman SM, Poon L, Saif L, Subbarao K, Turner M. Lancet. 2021 Jul 5:S0140-6736(21)01419-7. doi: 10.1016/S0140-6736(21)01419-7. Online ahead of print. PMID: 34237296

July 3

Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. Mattox TA, Psaltis C, Weihbrecht K, Robidoux J, Kilburg-Basnyat B, Murphy MP, Gowdy KM, Anderson EJ. J Am Heart Assoc. 2021 Jul 3:e019877. doi: 10.1161/JAHA.120.019877. Online ahead of print. PMID: 34219469

July 2

Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5-based COVID-19 vaccine. An D, Li K, Rowe DK, Diaz MCH, Griffin EF, Beavis AC, Johnson SK, Padykula I, Jones CA, Briggs K, Li G, Lin Y, Huang J, Mousa J, Brindley M, Sakamoto K, Meyerholz DK, McCray PB, Tompkins SM, He B. Sci Adv. 2021 Jul 2;7(27):eabi5246. doi: 10.1126/sciadv.abi5246. Print 2021 Jul. PMID: 34215591
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease. Dampalla CS, Kim Y, Bickmeier N, Rathnayake AD, Nguyen HN, Zheng J, Kashipathy MM, Baird MA, Battaile KP, Lovell S, Perlman S, Chang KO, Groutas WC. J Med Chem. 2021 Jul 2. doi: 10.1021/acs.jmedchem.1c00319. Online ahead of print. PMID: 34213885

July 1

August 25

Forty-Year Anniversary of Arteriosclerosis, Thrombosis, and Vascular Biology. Daugherty A, Fisher EA, Taubman MB, Heistad DD, Fogelman AM. Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2353-2356. doi: 10.1161/ATVBAHA.121.316755. Epub 2021 Aug 25. PMID: 34432483

August 24

Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity. Pack AD, Schwartzhoff PV, Zacharias ZR, Fernandez-Ruiz D, Heath WR, Gurung P, Legge KL, Janse CJ, Butler NS. Cell Rep. 2021 Aug 24;36(8):109586. doi: 10.1016/j.celrep.2021.109586. PMID: 34433049

August 19

Levofloxacin exerts broad-spectrum anticancer activity via regulation of THBS1, LAPTM5, SRD5A3, MFAP5 and P4HA1. He X, Yao Q, Hall DD, Song Z, Fan D, You Y, Lian W, Zhou Z, Duan L, Chen B. Anticancer Drugs. 2021 Aug 19. doi: 10.1097/CAD.0000000000001194. Online ahead of print. PMID: 34419964

Aug 18

Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR. Li H, Hostager BS, Arkee T, Bishop GA. J Biol Chem. 2021 Aug 18:101097. doi: 10.1016/j.jbc.2021.101097. Online ahead of print. PMID: 34418432
Respiratory Diseases Are Whole Body Diseases: Opportunities for Growth in Respiratory Physiology. Bates ML. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 18. doi: 10.1152/ajplung.00326.2021. Online ahead of print. PMID: 34405725

August 17

Clinical Correlation Between Vertical Gaze Palsy and Midbrain Volume in Progressive Supranuclear Palsy. Buch KA, Bouffard MA, Kardon RH, Wills AA, Privitera CM, Sharma M, Wray SH. J Neuroophthalmol. 2021 Aug 17. doi: 10.1097/WNO.0000000000001393. Online ahead of print. PMID: 34417776
Intrafamilial variability of ocular manifestations of von Hippel-Lindau disease. Bowen RC, Boldt HC, Mullins RF, Field MG, Affatigato LM, Hoffmann JM, Folk JC, Gehrs KM, Han IC, Sohn EH, Russell SR, Stone EM, Tucker BA, Binkley EM. Ophthalmol Retina. 2021 Aug 17:S2468-6530(21)00255-4. doi: 10.1016/j.oret.2021.08.005. Online ahead of print. PMID: 34416425

Aug 16

Bat intrusions at a tertiary care center in Iowa, 2018-2020. Alsuhaibani MA, Dains A, Kobayashi T, Sheeler LL, Trannel A, Holley S, Marra AR, Abosi OJ, Jenn KE, Meacham H, Etienne W, Kukla ME, Millard B, Wellington M, Diekema DJ, Salinas JL. Infect Control Hosp Epidemiol. 2021 Aug 16:1-3. doi: 10.1017/ice.2021.355. Online ahead of print. PMID: 34396947
Chronic high fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice. Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ. Am J Physiol Endocrinol Metab. 2021 Aug 16. doi: 10.1152/ajpendo.00144.2021. Online ahead of print. PMID: 34396783
The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain. Warwick CA, Keyes AL, Woodruff TM, Usachev YM. J Biol Chem. 2021 Aug 16:101085. doi: 10.1016/j.jbc.2021.101085. Review. Online ahead of print. PMID: 34411562

Aug 15

Effect of a Physician/Pharmacist Collaborative Care Model on Time in Target Range for Systolic Blood Pressure: Post Hoc Analysis of the CAPTION Trial. Dixon DL, Baker WL, Buckley LF, Salgado TM, Van Tassell BW, Carter BL. Hypertension. 2021 Aug 15 doi: 10.1161/HYPERTENSIONAHA.121.17873. Online ahead of print. PMID: 34397278

Aug 13

Stable Clostridioides difficile Infection Rates After the Discontinuation of Ultraviolet Light for Terminal Disinfection at a Tertiary Care Center, Iowa 2019-2020. Abosi OJ, Kobayashi T, Holley S, Kukla ME, Dains A, Alsuhaibani M, Marra AR, Jenn KE, Meacham H, Sheeler LL, Etienne W, Trannel A, Garringer J, Millard W, Diekema DJ, Edmond MB, Wellington M, Salinas JL. Am J Infect Control. 2021 Aug 13:S0196-6553(21)00521-6. doi: 10.1016/j.ajic.2021.08.005. Online ahead of print. PMID: 34400244

Aug 12

Computed tomography-assessed dysanapsis and airflow obstruction in early and mid adulthood. Vameghestahbanati M, Hiura GT, Barr RG, Sieren JC, Smith BM, Hoffman EA. Chest. 2021 Aug 12:S0012-3692(21)03665-5. doi: 10.1016/j.chest.2021.08.038. Online ahead of print. PMID: 34391757
Omega-3 Fatty Acid Dietary Supplements Consumed During Pregnancy and Lactation and Child Neurodevelopment: A Systematic Review. Nevins JEH, Donovan SM, Snetselaar L, Dewey KG, Novotny R, Stang J, Taveras EM, Kleinman RE, Bailey RL, Raghavan R, Scinto-Madonich SR, Venkatramanan S, Butera G, Terry N, Altman J, Adler M, Obbagy JE, Stoody EE, de Jesus J. J Nutr. 2021 Aug 12:nxab238. doi: 10.1093/jn/nxab238. Online ahead of print. PMID: 34383914
Racial/Ethnic Disparities in Alzheimer's Disease Risk: Role of Exposure to Ambient Fine Particles. Younan D, Wang X, Gruenewald T, Gatz M, Serre ML, Vizuete W, Braskie MN, Woods NF, Kahe K, Garcia L, Lurmann F, Manson JE, Chui HC, Wallace RB, Espeland MA, Chen JC. J Gerontol A Biol Sci Med Sci. 2021 Aug 12:glab231. doi: 10.1093/gerona/glab231. Online ahead of print. PMID: 34383042

Aug 9

Validation of Optical Genome Mapping for the Molecular Diagnosis of Facioscapulohumeral Muscular Dystrophy (FSHD). Stence AA, Thomason JG, Pruessner JA, Sompallae RR, Snow AN, Ma D, Moore SA, Bossler AD. J Mol Diagn. 2021 Aug 9:S1525-1578(21)00246-4. doi: 10.1016/j.jmoldx.2021.07.021. Online ahead of print. PMID: 34384893

August 7

Utility of high resolution mapping to guide ablation of ventricular arrhythmias from the aortic sinuses of Valsalva. Matto F, Venugopal D, Bhave PD, Rhodes TE, Mazur A. J Interv Card Electrophysiol. 2021 Aug 7. doi: 10.1007/s10840-021-01040-9. Online ahead of print. PMID: 34363567

August 4

Advancing Diagnostic Stewardship for Healthcare Associated Infections, Antibiotic Resistance, and Sepsis. Curren EJ, Lutgring JD, Kabbani S, Diekema DJ, Gitterman S, Lautenbach E, Morgan DJ, Rock C, Salerno RM, McDonald LC. Clin Infect Dis. 2021 Aug 4:ciab672. doi: 10.1093/cid/ciab672. Online ahead of print. PMID: 34346494
Hairpin transfer-independent Parvovirus DNA Replication Produces Infectious Virus. Shen W, Wang Z, Ning K, Cheng F, Engelhardt JF, Yan Z, Qiu J. J Virol. 2021 Aug 4:JVI0110821. doi: 10.1128/JVI.01108-21. Online ahead of print. PMID: 34346761
Relationship Between a Plant-Based Dietary Portfolio and Risk of Cardiovascular Disease: Findings From the Women's Health Initiative Prospective Cohort Study. Glenn AJ, Lo K, Jenkins DJA, Boucher BA, Hanley AJ, Kendall CWC, Manson JE, Vitolins MZ, Snetselaar LG, Liu S, Sievenpiper JL. J Am Heart Assoc. 2021 Aug 4:e021515. doi: 10.1161/JAHA.121.021515. Online ahead of print. PMID: 34346245

August 3

August 2

The Development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates. Ye G, Gallant J, Zheng J, Massey C, Shi K, Tai W, Odle A, Vickers M, Shang J, Wan Y, Du L Dr, Aihara H, Perlman S, LeBeau A, Li F. Elife. 2021 Aug 2;10:e64815. doi: 10.7554/eLife.64815. Online ahead of print. PMID: 34338634
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8. Sylvers-Davie KL, Davies BSJ. Am J Physiol Endocrinol Metab. 2021 Aug 2. doi: 10.1152/ajpendo.00195.2021. Online ahead of print. PMID: 34338039

August 1

Amygdala lesions reduce seizure-induced respiratory arrest in DBA/1 mice. Marincovich A, Bravo E, Dlouhy B, Richerson GB. Epilepsy Behav. 2021 Aug;121(Pt B):106440. doi: 10.1016/j.yebeh.2019.07.041. PMID: 31399338
Case Studies in Physiology: Temporal variations of the lung parenchyma and vasculature in asymptomatic COVID-19 pneumonia: a multispectral CT assessment. Nagpal P, Motahari A, Gerard SE, Guo J, Reinhardt JM, Comellas AP, Hoffman EA, Kaczka DW. J Appl Physiol. 2021 Aug 1;131(2):454-463. doi: 10.1152/japplphysiol.00147.2021. Epub 2021 Jun 24. PMID: 341660
Geodesic density regression for correcting 4DCT pulmonary respiratory motion artifacts. Shao W, Pan Y, Durumeric OC, Reinhardt JM, Bayouth JE, Rusu M, Christensen GE. Med Image Anal. 2021 Aug;72:102140. doi: 10.1016/j.media.2021.102140. Epub 2021 Jun 21. PMID: 34214957

Sept 30

The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways. Vu BG, Stamnes MA, Li Y, Rogers PD, Moye-Rowley WS. PLoS Genet. 2021 Sep 30;17(9):e1009582. doi: 10.1371/journal.pgen.1009582. Online ahead of print. PMID: 34591857
Sensitive quantification of m.3243A>G mutational proportion in non-retinal tissues and its relationship with visual symptoms. Mullin NK, Anfinson KR, Riker MJ, Wieland KL, Tatro NJ, Scheetz TE, Mullins RF, Stone EM, Tucker BA. Hum Mol Genet. 2021 Sep 30:ddab289. doi: 10.1093/hmg/ddab289. Online ahead of print. PMID: 34590675

Sept 29

A ketogenic diet protects DBA/1 and Scn1a^R1407X/+ mice against seizure-induced respiratory arrest independent of ketosis. Crotts MS, Kim Y, Bravo E, Richerson GB, Teran FA. Epilepsy Behav. 2021 Sep 29;124:108334. doi: 10.1016/j.yebeh.2021.108334. Online ahead of print. PMID: 34600281
Editorial for "Perfusion and Permeability Magnetic Resonance Imaging (MRI) Predicts Future Cavernous Angioma Hemorrhage and Growth". Hasan D. J Magn Reson Imaging. 2021 Sep 29. doi: 10.1002/jmri.27944. Online ahead of print. PMID: 34585810
Mortality Correlates in Takotsubo Syndrome Patients during the COVID-19 Pandemic. Chang A, Wang YG, Jayanna MB, Wu X, Cadaret LM, Liu K.Mayo Clin Proc Innov Qual Outcomes. 2021 Sep 29. doi: 10.1016/j.mayocpiqo.2021.09.008. Online ahead of print. PMID: 34604705

Sept 28

Dietary Advanced Glycation End-Products (AGEs) and Mortality After Breast Cancer in the Women's Health Initiative (WHI). Omofuma OO, Peterson LL, Turner DP, Merchant AT, Zhang J, Thomson CA, Neuhouser ML, Snetselaar L, Caan BJ, Shadyab AH, Saquib N, Banack HR, Uribarri J, Steck SE. Cancer Epidemiol Biomarkers Prev. 2021 Sep 28:cebp.0610.2021. doi: 10.1158/1055-9965.EPI-21-0610. PMID: 34583965
Quantification and image-derived phenotyping of retinal ganglion cell nuclei in the nee mouse model of congenital glaucoma. van der Heide CJ, Meyer KJ, Hedberg-Buenz A, Pellack D, Pomernackas N, Mercer HE, Anderson MG. Exp Eye Res. 2021 Sep 28:108774. doi: 10.1016/j.exer.2021.108774. Online ahead of print. PMID: 34597676

Sept 25

Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy. Smith SJ, Fabian L, Sheikh A, Noche R, Cui X, Moore SA, Dowling JJ. Hum Mol Genet. 2021 Sep 25:ddab278. doi: 10.1093/hmg/ddab278. Online ahead of print. PMID: 34568901
Patterns of medication use and imaging following initial diagnosis of sarcoidosis. Simmering J, Stapleton EM, Polgreen PM, Kuntz J, Gerke AK. Respir Med. 2021 Sep 25;189:106622. doi: 10.1016/j.rmed.2021.106622. Online ahead of print. PMID: 34600163

Sept 22

Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model. Joo NS, Cho HJ, Shinbashi M, Choi JY, Milla CE, Engelhardt JF, Wine JJ. Sci Rep. 2021 Sep 22;11(1):18828. doi: 10.1038/s41598-021-98122-5. PMID: 34552115
What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award. Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen P, Ouimet M, Sutton NR, Aikawa E. Arterioscler Thromb Vasc Biol. 2021 Sep 22 ATVBAHA121316558. doi: 10.1161/ATVBAHA.121.316558. PMID: 34547925

Sept 21

The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells. Devor EJ, Schickling BM, Lapierre JR, Bender DP, Gonzalez-Bosquet J, Leslie KK. Pharmaceuticals (Basel). 2021 Sep 21;14(9):942. doi: 10.3390/ph14090942.PMID: 34577642
Therapeutic potential of chemically modified, synthetic, triplex peptide nucleic acid-based oncomiR inhibitors for cancer therapy. Dhuri K, Gaddam RR, Vikram A, Slack FJ, Bahal R. Cancer Res. 2021 Sep 21:canres.0736.2021. doi: 10.1158/0008-5472.CAN-21-0736. Online ahead of print. PMID: 34548334

Sept 17

Interpreting SARS-CoV-2 Test Results. Coffey KC, Diekema DJ, Morgan DJ. JAMA. 2021 Sep 17. doi: 10.1001/jama.2021.16146. Online ahead of print. PMID: 34533581

Sept 16

Cooling down VITT with IVIG. Lentz SR. Blood. 2021 Sep 16;138(11):921-922. doi: 10.1182/blood.2021012819. PMID: 34529019

Sept 15

Calpain-2 Specifically Cleaves Junctophilin-2 at the Same Site as Calpain-1 but with Less Efficacy. Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall D, Song LS.Biochem J. 2021 Sep 15:BCJ20210629. doi: 10.1042/BCJ20210629. Online ahead of print.PMID: 34524407
Dual-Modality Poly-l-histidine Nanoparticles to Deliver Peptide Nucleic Acids and Paclitaxel for In Vivo Cancer Therapy. Wahane A, Malik S, Shih KC, Gaddam RR, Chen C, Liu Y, Nieh MP, Vikram A, Bahal R. ACS Appl Mater Interfaces. 2021 Sep 15. doi: 10.1021/acsami.1c11981. Online ahead of print. PMID: 34524806
Microvascular changes that stagger the mind. Faraci FM. J Clin Invest. 2021 Sep 15;131(18):e153202. doi: 10.1172/JCI153202. PMID: 34523619
Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI. Raghuram A, Varon A, Roa JA, Ishii D, Lu Y, Raghavan ML, Wu C, Magnotta VA, Hasan DM, Koscik TR, Samaniego EA. Sci Rep. 2021 Sep 15;11(1):18344. doi: 10.1038/s41598-021-97727-0 PMID: 34526579

Sept 14

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Tucker BA, Burnight ER, Cranston CM, Ulferts MJ, Luse MA, Westfall T, Scott CA, Marsden A, Gibson-Corley K, Wiley LA, Han IC, Slusarski DC, Mullins RF, Stone EM. Gene Ther. 2021 Sep 14. doi: 10.1038/s41434-021-00291-5. Online ahead of print. PMID: 34518651
Iron-Sulfur Cluster Biogenesis as a Critical Target in Cancer. Petronek MS, Spitz DR, Allen BG. Antioxidants (Basel). 2021 Sep 14;10(9):1458. doi: 10.3390/antiox10091458. PMID: 34573089. Review.

Sept 13

Physiology of slow pathway conduction during sinus rhythm: evidence from high density mapping within the triangle of Koch. Bailin SJ, Rhodes TE, Arter JC, Kocherla C, Kaushik N. J Interv Card Electrophysiol. 2021 Sep 13. doi: 10.1007/s10840-021-01061-4. Online ahead of print. PMID: 34518928
Postoperative cognitive dysfunction after endovascular treatments for unruptured intracranial aneurysms: A pilot study. Ishii D, Zanaty M, Roa JA, Li L, Lu Y, Allan L, Samaniego EA, Torner JC, Tranel D, Hasan DM. Interv Neuroradiol. 2021 Sep 13:15910199211039917. doi: 10.1177/15910199211039917. Online ahead of print. PMID: 34516320

Sept 10

Characterization of Catecholaldehyde Adducts with Carnosine and l-Cysteine Reveals Their Potential as Biomarkers of Catecholaminergic Stress. Crawford RA, Gilardoni E, Monroe TB, Regazzoni L, Anderson EJ, Doorn JA. Chem Res Toxicol. 2021 Sep 10. doi: 10.1021/acs.chemrestox.1c00153. Online ahead of print. PMID: 34506109
Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors. Krishnamurthy S, Traore S, Cooney AL, Brommel CM, Kulhankova K, Sinn PL, Newby GA, Liu DR, McCray PB. Nucleic Acids Res. 2021 Sep 14:gkab788. doi: 10.1093/nar/gkab788. Online ahead of print. PMID: 34520545

Sept 9

Associations of sleep duration and sleep-wake rhythm with lung parenchymal abnormalities on computed tomography: The MESA study. Kim JS, Dashti HS, Huang T, Cade BE, Podolanczuk AJ, O'Hearn DJ, Hoffman EA, Wang H, Blaikley J, Barr RG, Redline S. J Sleep Res. 2021 Sep 9:e13475. doi: 10.1111/jsr.13475. Online ahead of print. PMID: 34498326

Sept 7

Differential Effects of Prostaglandin D₂ Signaling on Macrophages and Microglia in Murine Coronavirus Encephalomyelitis. Verma AK, Zheng J, Mack M, Ginhoux F, Perlman S. mBio. 2021 Sep 7:e0196921. doi: 10.1128/mBio.01969-21. Online ahead of print. PMID: 34488442
Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Trial. Phipatanakul W, Koutrakis P, Coull BA, Petty CR, Gaffin JM, Sheehan WJ, Lai PS, Bartnikas LM, Kang CM, Wolfson JM, Samnaliev M, Cunningham A, Baxi SN, Permaul P, Hauptman M, Trivedi M, Louisias M, Liang L, Thorne PS, Metwali N, Adamkiewicz G, Israel E, Baccarelli AA, Gold DR; School Inner-City Asthma Intervention study team. JAMA. 2021 Sep 7;326(9):839-850. doi: 10.1001/jama.2021.11559. PMID: 34547084
Role of the WOR1 Promoter of Candida albicans in Opaque Commitment. Conway TP, Conway K, Boksa FA, Pujol C, Wessels D, Soll DR. mBio. 2021 Sep 7:e0232021. doi: 10.1128/mBio.02320-21. Online ahead of print. PMID: 34488444

Sept 6

Maternal Angiotensin II-Induced Hypertension Sensitizes Postweaning High-Fat Diet-Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring. Xue B, Yu Y, Beltz TG, Guo F, Felder RB, Wei SG, Kim Johnson A. J Am Heart Assoc. 2021 Sep 6:e022170. doi: 10.1161/JAHA.121.022170. Online ahead of print. PMID: 34482712

Sept 5

Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk? Harville EW, Crook CE, Bazzano LA, Woo JG, Burns TL, Raitakari O, Urbina EM, Venn A, Jacobs DR Jr, Steinberger J, Sinaiko A, Dwyer T, Juonala M; i3C Consortium. J Obstet Gynaecol Res. 2021 Sep 5. doi: 10.1111/jog.14971. Online ahead of print. PMID: 34482586

Sept 4

Predictors of aneurysm occlusion following treatment with the WEB device: systematic review and case series. Al Saiegh F, Velagapudi L, Khanna O, Sweid A, Mouchtouris N, Baldassari MP, Theofanis T, Tahir R, Schunemann V, Andrews C, Philipp L, Chalouhi N, Tjoumakaris SI, Hasan D, Gooch MR, Herial NA, Rosenwasser RH, Jabbour P. Neurosurg Rev. 2021 Sep 4. doi: 10.1007/s10143-021-01638-7. Online ahead of print. PMID: 34480649 Review.
Spatio-temporal hybrid neural networks reduce erroneous human "judgement calls" in the diagnosis of Takotsubo syndrome. Zaman F, Ponnapureddy R, Wang YG, Chang A, Cadaret LM, Abdelhamid A, Roy SD, Makan M, Zhou R, Jayanna MB, Gnall E, Dai X, Singh A, Zheng J, Boppana VS, Wang F, Singh P, Wu X, Liu K. EClinicalMedicine. 2021 Sep 4;40:101115. doi: 10.1016/j.eclinm.2021.101115. PMID: 34522872

Sept 3

FUNCTIONAL RESILIENCE OF C57BL/6J MOUSE HEART TO DIETARY FAT OVERLOAD. Tadinada SM, Weatherford ET, Collins GV, Bhardwaj G, Cochran J, Kutschke W, Zimmerman K, Bosko A, O'Neill BT, Weiss RM, Abel ED. Am J Physiol Heart Circ Physiol. 2021 Sep 3. doi: 10.1152/ajpheart.00419.2021. Online ahead of print. PMID: 34477461
The genomics of heart failure: design and rationale of the HERMES consortium. Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C, Verweij N, Holmes MV, Ärnlöv J, Svensson P, Hemingway H, Sallah N, Almgren P, Aragam KG, Asselin G, Backman JD, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunner-La Rocca HP, Carey DJ, Chaffin MD, Chasman DI, Chazara O, Chen X, Chen X, Chung JH, Chutkow W, Cleland JGF, Cook JP, de Denus S, Dehghan A, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Engström G, Esko T, Fatemifar G, Felix SB, Finan C, Ford I, Fougerousse F, Fouodjio R, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Haggerty CM, van der Harst P, Hedman ÅK, Helgadottir A, Hillege H, Hyde CL, Jacob J, Jukema JW, Kamanu F, Kardys I, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Kraus B, Kuchenbaecker K, Langenberg C, Lind L, Lindgren CM, London B, et al. ESC Heart Fail. 2021 Sep 3. doi: 10.1002/ehf2.13517. Online ahead of print. PMID: 34480422

Sept 2

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC. Nat Commun. 2021 Sep 2;12(1):5249. doi: 10.1038/s41467-021-25380-2. PMID: 34475397
Phase 1/2a Trial of ISPASM. Zanaty M, Allan L, Samaniego EA, Piscopo A, Ryan E, Torner JC, Hasan D. Stroke. 2021 Sep 2:STROKEAHA121034578. doi: 10.1161/STROKEAHA.121.034578. Online ahead of print. PMID: 34470496

Sept 1

Oct 30

Analysis of multiple gene co-expression networks to discover interactions favoring CFTR biogenesis and ΔF508-CFTR rescue. Strub MD, Gao L, Tan K, McCray PB Jr. BMC Med Genomics. 2021 Oct 30;14(1):258. doi: 10.1186/s12920-021-01106-7. PMID: 34717611

Oct 29

Altering Early Life Gut Microbiota Has Long-Term Effect on Immune System and Hypertension in Spontaneously Hypertensive Rats. Abboud FM, Cicha MZ, Ericsson A, Chapleau MW, Singh MV. Front. Physiol., 29 Oct 2021. Volume 12. doi.org/10.3389/fphys.2021.7529
Post-acquisition CO₂ Inhalation Enhances Fear Memory and Depends on ASIC1A. Taugher RJ, Wunsch AM, Wang GZ, Chan AC, Dlouhy BJ, Wemmie JA. Front Behav Neurosci. 2021 Oct 29;15:767426. doi: 10.3389/fnbeh.2021.767426. eCollection 2021. PMID: 34776896

Oct 28

Intersubject Variation in ACE2 Protein Expression in Human Airway Epithelia and Its Relationship to Severe Acute Respiratory Syndrome Coronavirus 2. Li K, Wohlford-Lenane C, Bartlett JA, McCray PB. J Infect Dis. 2021 Oct 28;224(8):1357-1361. doi: 10.1093/infdis/jiab383.PMID: 34289058
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein. Littler DR, Liu M, McAuley JL, Lowery SA, Illing PT, Gully BS, Purcell AW, Chandrashekaran IR, Perlman S, Purcell DFJ, Quinn RJ, Rossjohn J. J Biol Chem. 2021 Oct 28:101362. doi: 10.1016/j.jbc.2021.101362. Online ahead of print. PMID: 34756886

Oct 27

Association of Patient-Reported Physician Awareness of Complementary Medicine, Medical Care Experience and Care Quality. Roydhouse JK, Wilson IB, Gutman R, Wallace RB, Berman T, Keating NL. J Patient Exp. 2021 Oct 27;8:23743735211049665. doi: 10.1177/23743735211049665. eCollection 2021. PMID: 34722868
Combined inorganic nitrate/nitrite supplementation blunts α-mediated vasoconstriction during exercise in patients with type 2 diabetes. Bock JM, Ueda K, Feider AJ, Hanada S, Casey DP. Nitric Oxide. 2021 Oct 27:S1089-8603(21)00110-5. doi: 10.1016/j.niox.2021.10.006. Online ahead of print. PMID: 34718145
Flow Monitoring of ECMO Circuit for Detecting Oxygenator Obstructions. Sarathy S, Turek JW, Chu J, Badheka A, Nino MA, Raghavan ML. Ann Biomed Eng. 2021 Oct 27. doi: 10.1007/s10439-021-02878-w. Online ahead of print. PMID: 34705123
Mice with diverse microbial exposure histories as a model for preclinical vaccine testing. Fiege JK, Block KE, Pierson MJ, Nanda H, Shepherd FK, Mickelson CK, Stolley JM, Matchett WE, Wijeyesinghe S, Meyerholz DK, Vezys V, Shen SS, Hamilton SE, Masopust D, Langlois RA. Cell Host Microbe. 2021 Oct 27:S1931-3128(21)00463-7. doi: 10.1016/j.chom.2021.10.001. Online ahead of print. PMID: 34731647
Redox sensitive miR-27a/b/Nrf2 signaling in Cr(VI)-induced carcinogenesis. Wang L, Bayanbold K, Zhao L, Wang Y, Adamcakova-Dodd A, Thorne PS, Yang H, Jiang BH, Liu LZ. Sci Total Environ. 2021 Oct 27:151118. doi: 10.1016/j.scitotenv.2021.151118. Online ahead of print. PMID: 34718002
Trends in Mortality From Parkinson Disease in the United States, 1999-2019. Rong S, Xu G, Liu B, Sun Y, Snetselaar LG, Wallace RB, Li B, Liao J, Bao W. Neurology. 2021 Oct 27:10.1212/WNL.0000000000012826. doi: 10.1212/WNL.0000000000012826. Online ahead of print. PMID: 34706971

Oct 21

Computed Tomography Perfusion-Based Prediction of Core Infarct and Tissue at Risk: Can Artificial Intelligence Help Reduce Radiation Exposure? Bathla G, Liu Y, Zhang H, Sonka M, Derdeyn C. Stroke. 2021 Oct 21:STROKEAHA121034266. doi: 10.1161/STROKEAHA.121.034266. Online ahead of print. PMID: 34670412
Dietary and complementary feeding practices of U.S. infants, 6-12 months: A narrative review of the Federal nutrition monitoring data. Bailey RL, Stang JS, Davis TA, Naimi TS, Schneeman BO, Dewey KG, Donovan SM, Novotny R, Kleinman RE, Taveras EM, Bazzano L, Snetselaar LG, de Jesus J, Casavale KO, Stoody EE, Goldman JD, Moshfegh AJ, Rhodes DG, Herrick KA, Koegel K, Perrine CG, Pannucci T. J Acad Nutr Diet. 2021 Oct 21:S2212-2672(21)01384-8. doi: 10.1016/j.jand.2021.10.017. Online ahead of print. PMID: 34688966
Effects of Tham Nasal Alkalinization on Airway Microbial Communities: A Pilot Study in Non-CF and CF Adults. Holliday ZM, Launspach JL, Durairaj L, Singh PK, Zabner J, Stoltz DA. Ann Otol Rhinol Laryngol. 2021 Oct 21:34894211051814. doi: 10.1177/00034894211051814. Online ahead of print. PMID: 34674574
Quantum chemical insight into the effects of the local electron environment on T₂*-based MRI. Petronek MS, St-Aubin JJ, Lee CY, Spitz DR, Gillan EG, Allen BG, Magnotta VA. Sci Rep. 2021 Oct 21;11(1):20817. doi: 10.1038/s41598-021-00305-7. PMID: 34675308

Oct 20

CRIF1 Deficiency Increased Homocysteine Production by Disrupting Dihydrofolate Reductase Expression in Vascular Endothelial Cells. Lee I, Piao S, Kim S, Nagar H, Choi SJ, Jeon BH, Oh SH, Irani K, Kim CS. Antioxidants (Basel). 2021 Oct 20;10(11):1645. doi: 10.3390/antiox10111645. PMID: 34829516
Radiation-induced airway changes and downstream ventilation decline in a swine model. Wallat EM, Wuschner AE, Flakus MJ, Christensen GE, Reinhardt JM, Shanmuganayagam D, Bayouth JE. Biomed Phys Eng Express. 2021 Oct 20. doi: 10.1088/2057-1976/ac3197. Online ahead of print. PMID: 34670195

Oct 19

Interpreting SARS-CoV-2 Test Results. Coffey KC, Diekema DJ, Morgan DJ. JAMA. 2021 Oct 19;326(15):1528-1529. doi: 10.1001/jama.2021.16146. PMID: 34533581

Oct 15

Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. Wang J, Ciampa G, Zheng D, Shi Q, Chen B, Abel ED, Peng T, Hall DD, Song LS. Biochem J. 2021 Oct 15;478(19):3539-3553. doi: 10.1042/BCJ20210629. PMID: 34524407
Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by Amiloride via Multiple Mechanisms and Sites Within the Channel. Matasic DS, Holland N, Gautam M, Gibbons DD, Kusama N, Harding AMS, Shah VS, Snyder PM, Benson CJ. Front Physiol. 2021 Oct 15;12:750696. doi: 10.3389/fphys.2021.750696. eCollection 2021. PMID: 34721074

Oct 14

The mechanism of cell death induced by silver nanoparticles is distinct from silver cations. Rohde MM, Snyder CM, Sloop J, Solst SR, Donati GL, Spitz DR, Furdui CM, Singh R. Part Fibre Toxicol. 2021 Oct 14;18(1):37. doi: 10.1186/s12989-021-00430-1. PMID: 34649580

Oct 13

2021 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19. Hsu A, Sasson C, Kudenchuk PJ, Atkins DL, Aziz K, Becker LB, Berg RA, Bhanji F, Bradley SM, Brooks SC, Chan M, Chan PS, Cheng A, Clemency BM, de Caen A, Duff JP, Edelson DP, Flores GE, Fuchs S, Girotra S, Hinkson C, Joyner BL Jr, Kamath-Rayne BD, Kleinman M, Lasa JJ, Lavonas EJ, Lee HC, Lehotzky RE, Levy A, Mancini ME, McBride ME, Meckler G, Merchant RM, Moitra VK, Morgan RW, Nadkarni V, Panchal AR, Peberdy MA, Raymond T, Roberts K, Sayre MR, Schexnayder SM, Sutton RM, Terry M, Walsh B, Wang DS, Zelop CM, Topjian A; Emergency Cardiovascular Care Committee and Get With the Guidelines-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration With the American Academy of Pediatrics, American Association for Respiratory Care, American College of Emergency Physicians, American Society of Anesthesiologists, and the Society of Critical Care Anesthesiologists. Circ Cardiovasc Qual Outcomes. 2021 Oct 13: CIRCOUTCOMES121008396. doi: 10.1161/CIRCOUTCOMES.121.008396. Online ahead of print. PMID: 34641719

Oct 11

IL (Interleukin)-17A Acts in the Brain to Drive Neuroinflammation, Sympathetic Activation, and Hypertension. Cao Y, Yu Y, Xue B, Wang Y, Chen X, Beltz TG, Johnson AK, Wei SG. Hypertension. 2021 Nov;78(5):1450-1462. doi: 10.1161/HYPERTENSIONAHA.121.18219. Epub 2021 Oct 11. PMID: 34628936

Oct 8

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy. Mehdi Z, Petronek MS, Stolwijk JM, Mapuskar KA, Kalen AL, Buettner GR, Cullen JJ, Spitz DR, Buatti JM, Allen BG. Int J Mol Sci. 2021 Oct 8;22(19):10880. doi: 10.3390/ijms221910880. Review. PMID: 34639220
The Woven EndoBridge (WEB) device: feasibility, techniques, and outcomes after FDA approval. Mouchtouris N, Hasan D, Samaniego EA, Saiegh FA, Sweid A, Abbas R, Naamani KE, Tahir R, Zanaty M, Khanna O, Chalouhi N, Tjoumakaris S, Gooch MR, Rosenwasser R, Jabbour P. J Neurosurg. 2021 Oct 8:1-7. doi: 10.3171/2021.5.JNS21889. Online ahead of print. PMID: 34624864

Oct 7

Investigating Predictors of Preserved Cognitive Function in Older Women Using Machine Learning: Women's Health Initiative Memory Study. Casanova R, Gaussoin SA, Wallace R, Baker L, Chen JC, Manson JE, Henderson VW, Sachs BC, Justice J, Whitsel EA, Hayden KM, Rapp SR. J Alzheimers Dis. 2021 Oct 7. doi: 10.3233/JAD-210621. Online ahead of print. PMID: 34633318

Oct 5

A Catecholaldehyde Metabolite of Norepinephrine Induces Myofibroblast Activation and Toxicity via the Receptor for Advanced Glycation Endproducts: Mitigating Role of l-Carnosine. Monroe TB, Anderson EJ. Chem Res Toxicol. 2021 Oct 5. doi: 10.1021/acs.chemrestox.1c00262. Online ahead of print. PMID: 34609854
Change in Micronutrient Intake among People with Relapsing-Remitting Multiple Sclerosis Adapting the Swank and Wahls Diets: An Analysis of Weighed Food Records. Titcomb TJ, Brooks L, Smith KL, Ten Eyck P, Rubenstein LM, Wahls TL, Snetselaar LG. Nutrients. 2021 Oct 5;13(10):3507. doi: 10.3390/nu13103507. PMID: 34684508

Oct 4

Prevalence Implications of the 2017 American Academy of Pediatrics Hypertension Guideline and Associations with Adult Hypertension. Khoury M, Khoury P, Bazzano L, Burns TL, Daniels S, Dwyer T, Ikonen J, Jacobs DR Jr, Juonala M, Kähönen M, Prineas R, Raitakari OT, Steinberger J, Venn A, Viikari J, Woo JG, Sinaiko A, Urbina EM. J Pediatr. 2021 Oct 4:S0022-3476(21)00959-8. doi: 10.1016/j.jpeds.2021.09.056. Online ahead of print. PMID: 34619113
Quantifying the Onset of Unintended Weight Loss in Huntington's Disease: A Retrospective Analysis of Enroll-HD. Ogilvie AC, Nopoulos PC, Schultz JL. J Huntingtons Dis. 2021 Oct 4. doi: 10.3233/JHD-210488. Online ahead of print. PMID: 34633327

Oct 2

Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder. Shaffer JJ Jr, Willour V, Fiedorowicz JG, Christensen GE, Long JD, Johnson CP, Schmitz SL, Williams AJ, Wemmie J, Magnotta VABrain Imaging Behav. 2021 Oct 2. doi: 10.1007/s11682-021-00552-2. Online ahead of print. PMID: 34601647
Electron Spin Resonance Evaluation of Buccal Membrane Fluidity Alterations by Sodium Caprylate and L-Menthol. Chede LS, Wagner BA, Buettner GR, Donovan MD. Int J Mol Sci. 2021 Oct 2;22(19):10708. doi: 10.3390/ijms221910708. PMID: 34639049

Oct 1

Nov 29

The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Simonsen D, Cady N, Zhang C, Shrode RL, McCormick ML, Spitz DR, Chimenti MS, Wang K, Mangalam A, Lehmler HJ. Toxicol Sci. 2021 Nov 29:kfab142. doi: 10.1093/toxsci/kfab142. PMID: 34850242
Optimal Urine Culture Diagnostic Stewardship Practice- Results from an Expert Modified-Delphi Procedure. Claeys KC, Trautner BW, Leekha S, Coffey KC, Crnich CJ, Diekema D, Fakih MG, Goetz MB, Gupta K, Jones MM, Leykum L, Liang SY, Pineles L, Pleiss A, Spivak ES, Suda KJ, Taylor J, Rhee C, Morgan DJ. Clin Infect Dis. 2021 Nov 29:ciab987. doi: 10.1093/cid/ciab987. PMID: 34849637

Nov 27

A pilot to assess target engagement of terazosin in Parkinson's disease. Schultz JL, Brinker AN, Xu J, Ernst SE, Tayyari F, Rauckhorst AJ, Liu L, Uc EY, Taylor EB, Simmering JE, Magnotta VA, Welsh MJ, Narayanan NS. Parkinsonism Relat Disord. 2021 Nov 27;94:79-83. doi: 10.1016/j.parkreldis.2021.11.022. PMID: 34894470
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: an overview of Network organization, procedures and interventions. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Alexander LC, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P; PrecISE Study Team. J Allergy Clin Immunol. 2021 Nov 27:S0091-6749(21)01819-4. doi: 10.1016/j.jaci.2021.10.035. PMID: 34848210

Nov 26

Conditional Gene Targeting Using UCP1-Cre Mice Directly Targets the Central Nervous System Beyond Thermogenic Adipose Tissues. Claflin KE, Flippo KH, Sullivan AI, Naber MC, Zhou B, Neff TJ, Jensen-Cody SO, Potthoff MJ. Mol Metab. 2021 Nov 26:101405. doi: 10.1016/j.molmet.2021.101405. PMID: 34844020
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy? Wong LR, Perlman S. Nat Rev Immunol. 2021 Nov 26:1-10. doi: 10.1038/s41577-021-00656-2. PMID: 34837062

Nov 24

Impact of the Three COVID-19 Surges in 2020 on In-Hospital Cardiac Arrest Survival in the United States. Gupta K, Girotra S, Nallamothu BK, Kennedy K, Starks MA, Chan PS; American Heart Association's Get With the Guidelines®-Resuscitation Investigators listed in Supplementary Appendix. Resuscitation. 2021 Nov 24:S0300-9572(21)00479-2. doi: 10.1016/j.resuscitation.2021.11.025. PMID: 34838661
Self-controlled assessment of thromboembolic event (TEE) risk following intravenous immune globulin (IGIV) in the U.S. (2006-2012). Ammann EM, Chrischilles EA, Carnahan RM, Fireman B, Fuller CC, Schweizer ML, Garcia C, Pimentel M, Leonard CE, Baker MA, Cuker A, Leira EC, Robinson JG, Winiecki SK. J Thromb Thrombolysis. 2021 Nov 24. doi: 10.1007/s11239-021-02610-4. PMID: 34817789

Nov 23

Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial. Bellingan G, Jacono F, Bannard-Smith J, Brealey D, Meyer N, Thickett D, Young D, Bentley A, McVerry BJ, Wunderink RG, Doerschug KC, Summers C, Rojas M, Ting A, Jenkins ED. Intensive Care Med. 2021 Nov 23:1-9. doi: 10.1007/s00134-021-06570-4. PMID: 34811567

Nov 22

Diabetes Device Downloading: Benefits and Barriers Among Youth With Type 1 Diabetes. Palmer BA, Soltys K, Zimmerman MB, Norris AW, Tsalikian E, Tansey MJ, Pinnaro CT. J Diabetes Sci Technol. 2021 Nov 22:19322968211059537. doi: 10.1177/19322968211059537. PMID: 34809477
Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations. Singh U, Jiang J, Saito K, Toth BA, Dickey JE, Rodeghiero SR, Deng Y, Deng G, Xue B, Zhu Z, Zingman LV, Geerling JC, Cui H. Mol Metab. 2021 Nov 22:101401. doi: 10.1016/j.molmet.2021.101401. PMID: 34823066

Nov 18

Atrial-paced, exercise-similar heart rate envelope induces myocardial protection from ischaemic injury. Zhu Z, Gao Z, Chen B, Hall DD, Minerath R, Koval O, Sierra A, Subbotina E, Zhu X, Kim YR, Yang J, Grumbach I, Irani K, Grueter C, Song LS, Hodgson-Zingman DM, Zingman LV. Europace. 2021 Nov 18:euab273. doi: 10.1093/europace/euab273. PMID: 34792112
A computational model of contributors to pulmonary hypertensive disease: impacts of whole lung and focal disease distributions. Ebrahimi BS, Tawhai MH, Kumar H, Burrowes KS, Hoffman EA, Wilsher ML, Milne D, Clark AR. Pulm Circ. 2021 Nov 18; 11(4):20458940211056527. doi: 10.1177/20458940211056527. PMID: 34820115
Influence of SARS-CoV-2 on airway mucus production: A review and proposed model. Meyerholz DK, Reznikov LR. Vet Pathol. 2021 Nov 18:3009858211058837. doi: 10.1177/03009858211058837. PMID: 34794359

Nov 16

ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. Sebag SC, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, Li W, Zingman LV, Liu L, Lira VA, Potthoff MJ, Bartelt A, Yang L. Cell Rep. 2021 Nov 16;37(7):110003. doi: 10.1016/j.celrep.2021.110003. PMID: 34788615

Nov 15

Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences. Pierce GL, Coutinho TA, DuBose LE, Donato AJ. Physiology (Bethesda). 2021 Nov 15. doi: 10.1152/physiol.00035.2021. Online ahead of print. PMID: 34779281

Nov 12

JAND Editor in Chief response to LTE 'IDEA: Let's design, conduct, and report research with diversity and inclusion in mind'. Snetselaar L. J Acad Nutr Diet. 2021 Nov 12:S2212-2672(21)01378-2. doi: 10.1016/j.jand.2021.10.011. Online ahead of print. PMID: 34782301

Nov 11

Reversible bilateral optic tract edema following pipeline-assisted coiling of a large ophthalmic aneurysm: A case report. Osorno-Cruz C, Piscopo A, Raghuram A, Sanchez S, Samaniego E, Hasan D. Clin Neurol Neurosurg. 2021 Nov 11;211:107029. doi: 10.1016/j.clineuro.2021.107029. PMID: 34794059

Nov 10

Nov 9

The Challenges and Opportunities in the Development of MicroRNA Therapeutics: A Multidisciplinary Viewpoint. Momin MY, Gaddam RR, Kravitz M, Gupta A, Vikram A. Cells. 2021 Nov 9;10(11):3097. doi: 10.3390/cells10113097. PMID: 34831320
Prostate-Specific Membrane Antigen (PSMA) Theranostics for Treatment of Oligometastatic Prostate Cancer. Plichta KA, Graves SA, Buatti JM. Int J Mol Sci. 2021 Nov 9;22(22):12095. doi: 10.3390/ijms222212095. PMID: 34829977
Significance of FEV₃/FEV₆ in recognition of early airway disease in smokers at risk of development of COPD: Analysis of the SPIROMICS cohort. Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ. Chest. 2021 Nov 9:S0012-3692(21)04276-8. doi: 10.1016/j.chest.2021.10.046. Online ahead of print. PMID: 34767825

Nov 8

Assessing Predictors of Rheumatoid Arthritis Associated Interstitial Lung Disease using Quantitative Lung Densitometry. Alevizos MK, Danoff SK, Pappas DA, Lederer DJ, Johnson C, Hoffman EA, Bernstein EJ, Bathon JM, Giles JT. Rheumatology (Oxford). 2021 Nov 8:keab828. doi: 10.1093/rheumatology/keab828. PMID: 34747452
Community-level Economic Distress, Race, and Risk of Adverse Outcomes Following Heart Failure Hospitalization among Medicare Beneficiaries. Mentias A, Desai MY, Vaughan-Sarrazin MS, Rao S, Morris AA, Hall JL, Menon V, Hockenberry J, Sims M, Fonarow GC, Girotra S, Pandey A. Circulation. 2021 Nov 8. doi: 10.1161/CIRCULATIONAHA.121.057756. PMID: 34743555
IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes. Greenbaum CJ, Serti E, Lambert K, Weiner LJ, Kanaparthi S, Lord S, Gitelman SE, Wilson DM, Gaglia JL, Griffin KJ, Russell WE, Raskin P, Moran A, Willi SM, Tsalikian E, DiMeglio LA, Herold KC, Moore WV, Goland R, Harris M, Craig ME, Schatz DA, Baidal DA, Rodriguez H, Utzschneider KM, Nel HJ, Soppe CL, Boyle KD, Cerosaletti K, Keyes-Elstein L, Long SA, Thomas R, McNamara JG, Buckner JH, Sanda S; ITN058AI EXTEND Study Team. JCI Insight. 2021 Nov 8;6(21):e150074. doi: 10.1172/jci.insight.150074. PMID: 34747368

Nov 7

Global and regional white matter fractional anisotropy in children with chronic kidney disease. van der Plas E, Solomon MA, Hopkins L, Koscik T, Schultz J, Brophy PD, Nopoulos PC, Harshman LA. J Pediatr. 2021 Nov 7:S0022-3476(21)01071-4. doi: 10.1016/j.jpeds.2021.11.006. PMID: 34758354

Nov 5

Decreased expression of glial-derived neurotrophic factor receptors in glaucomatous human retinas. Akurathi A, Boese EA, Kardon RH, Ledolter J, Kuehn MH, Harper MM. Curr Eye Res. 2021 Nov 5. doi: 10.1080/02713683.2021.2002907. PMID: 34738835

Nov 3

Urban particulate matter impairs airway-surface-liquid-mediated coronavirus inactivation. Stapleton EM, Welch JL, Ubeda EA, Xiang J, Zabner J, Thornell IM, Nonnenmann MW, Stapleton JT, Comellas AP. J Infect Dis. 2021 Nov 3:jiab545. doi: 10.1093/infdis/jiab545. PMID: 34734257

Nov 2

Coronavirus Disease 2019 Serial Testing Among Hospitalized Patients in a Midwest Tertiary Medical Center, July-September 2020. Kobayashi T, Trannel A, Holley SA, Alsuhaibani MA, Abosi OJ, Jenn KE, Meacham H, Sheeler LL, Etienne W, Dains A, Casado F, Kukla ME, Ward EK, Ford B, Edmond MB, Wellington M, Diekema DJ, Salinas JL. Clin Infect Dis. 2021 Nov 2;73(9):e3116-e3119. doi: 10.1093/cid/ciaa1630. PMID: 33103196
Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium. Nuotio J, Laitinen TT, Sinaiko AR, Woo JG, Urbina EM, Jacobs DR Jr, Steinberger J, Prineas RJ, Sabin MA, Burgner DP, Minn H, Burns TL, Bazzano LA, Venn AJ, Viikari JSA, Hutri-Kähönen N, Daniels SR, Raitakari OT, Magnussen CG, Juonala M, Dwyer T. Int J Obes (Lond). 2021 Nov 2. doi: 10.1038/s41366-021-01000-3. Online ahead of print. PMID: 34728776

Nov 1

Dec 31

The Interaction of Vitamin D and Corticosteroids: A Mortality Analysis of 26,508 Veterans Who Tested Positive for SARS-CoV-2. Efird JT, Anderson EJ, Jindal C, Redding TS, Thompson AD, Press AM, Upchurch J, Williams CD, Choi YM, Suzuki A. Int J Environ Res Public Health. 2021 Dec 31;19(1):447. doi: 10.3390/ijerph19010447. PMID: 35010701

Dec 28

A splice site mutation in the TSEN2 causes a new syndrome with craniofacial and central nervous system malformations, and atypical hemolytic uremic syndrome. Canpolat N, Liu D, Atayar E, Saygili S, Kara NS, Westfall TA, Ding Q, Brown BJ, Braun TA, Slusarski D, Oguz KK, Ozluk Y, Tuysuz B, Tastemel Ozturk T, Sever L, Sezerman OU, Topaloglu R, Caliskan S, Attanasio M, Ozaltin F. Clin Genet. 2021 Dec 28. doi: 10.1111/cge.14105. PMID: 34964109

Dec 27

Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, Talley JJ, Adams CM. J Nutr. 2021 Dec 27:nxab440. doi: 10.1093/jn/nxab440. PMID: 34958390
Sex Differences in the Association of Pre-Transfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant. Benavides A, Bell EF, Conrad AL, Feldman HA, Georgieff MK, Josephson CD, Koscik T, Stowell SR, Sola-Visner M, Nopoulos P. J Pediatr. 2021 Dec 27:S0022-3476(21)01258-0. doi: 10.1016/j.jpeds.2021.12.051. PMID: 34968498
Transforming Growth Factor-α Acts in Hypothalamic Paraventricular Nucleus to Upregulate ERK1/2 Signaling and Expression of Sympathoexcitatory Mediators in Heart Failure Rats. Yu Y, Chen E, Weiss RM, Felder RB, Wei SG. Neuroscience. 2021 Dec 27:S0306-4522(21)00654-0. doi: 10.1016/j.neuroscience.2021.12.030. PMID: 34968668

Dec 24

Outcomes of peroral endoscopic myotomy in patients with achalasia and prior bariatric surgery: A multicenter experience. Bomman S, Klair JS, Ashat M, El Abiad R, Gerke H, Keech J, Parekh K, Nau P, Hanada Y, Wong Kee Song LM, Kozarek R, Irani S, Low D, Ross A, Krishnamoorthi R. Dis Esophagus. 2021 Dec 24;34(12):doab044. doi: 10.1093/dote/doab044. PMID: 34184036

Dec 22

Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis. Ollinger TL, Vu B, Murante D, Parker JE, Simonicova L, Doorley L, Stamnes MA, Kelly SL, Rogers PD, Moye-Rowley WS, Krysan DJ. mSphere. 2021 Dec 22;6(6):e0083021. doi: 10.1128/msphere.00830-21. Epub 2021 Dec 22. PMID: 34935446

Dec 21

Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections. Durfey SL, Pipavath S, Li A, Vo AT, Ratjen A, Carter S, Morgan SJ, Radey MC, Grogan B, Salipante SJ, Welsh MJ, Stoltz DA, Goss CH, McKone EF, Singh PK. mBio. 2021 Dec 21;12(6):e0314821. doi: 10.1128/mbio.03148-21. Epub 2021 Dec 14. PMID: 34903059. Clinical Trial.

Dec 20

Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities. Kim JS, Axelsson GT, Moll M, Anderson MR, Bernstein EJ, Putman RK, Hida T, Hatabu H, Hoffman EA, Raghu G, Kawut SM, Doyle MF, Tracy R, Launer LJ, Manichaikul A, Rich SS, Lederer DJ, Gudnason V, Hobbs BD, Cho MH, Hunninghake GM, Garcia CK, Gudmundsson G, Barr RG, Podolanczuk AJ. Am J Respir Crit Care Med. 2021 Dec 20. doi: 10.1164/rccm.202108-1967OC. PMID: 34929108
Menstrual cycle impacts lung structure measures derived from quantitative computed tomography. Sieren JC, Schroeder KE, Guo J, Asosingh K, Erzurum S, Hoffman EA. Eur Radiol. 2021 Dec 20. doi: 10.1007/s00330-021-08404-9. PMID: 34928413
Retinal ciliopathies through the lens of Bardet-Biedl Syndrome: Past, present and future. Chandra B, Tung ML, Hsu Y, Scheetz T, Sheffield VC. Prog Retin Eye Res. 2021 Dec 17:101035. doi: 10.1016/j.preteyeres.2021.101035. Review. PMID: 34929400

Dec 15

Days of Antibiotic Spectrum Coverage (DASC): A Novel Metric for Inpatient Antibiotic Consumption. Kakiuchi S, Livorsi DJ, Perencevich EN, Diekema DJ, Ince D, Prasidthrathsint K, Kinn P, Percival K, Heintz BH, Goto M. Clin Infect Dis. 2021 Dec 15:ciab1034. doi: 10.1093/cid/ciab1034. PMID: 34910130

Dec 14

Clinical characteristics of COVID-19 in solid organ transplant recipients following COVID-19 vaccination: A multicenter case series. Saharia K, Anjan S, Streit J, Beekmann SE, Polgreen PM, Kuehnert M, Segev DL, Baddley JW, Miller RA. Transpl Infect Dis. 2021 Dec 14. doi: 10.1111/tid.13774. PMID: 34905269
Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections. Durfey SL, Pipavath S, Li A, Vo AT, Ratjen A, Carter S, Morgan SJ, Radey MC, Grogan B, Salipante SJ, Welsh MJ, Stoltz DA, Goss CH, McKone EF, Singh PK. mBio. 2021 Dec 14:e0314821. doi: 10.1128/mbio.03148-21. PMID: 34903059

Dec 13

Validation of blood arsenic and manganese assessment from archived clotted erythrocyte fraction in an urban cohort of mother-child dyads. Haque E, Moran ME, Wang H, Adamcakova-Dodd A, Thorne PS. Sci Total Environ. 2021 Dec 13;810:152320. doi: 10.1016/j.scitotenv.2021.152320. PMID: 34915002

Dec 10

AAV-mediated gene editing lights up the lung. Yan Z, Lynch TJ, Engelhardt JF. Mol Ther. 2021 Dec 10:S1525-0016(21)00639-0. doi: 10.1016/j.ymthe.2021.12.003. PMID: 34895514
Analysis of Cerebral Aneurysm Wall Tension and Enhancement Using Finite Element Analysis and High-Resolution Vessel Wall Imaging. Galloy AE, Raghuram A, Nino MA, Varon Miller A, Sabotin R, Osorno-Cruz C, Samaniego EA, Raghavan SML, Hasan D. Front Neurol. 2021 Dec 10;12:764063. doi: 10.3389/fneur.2021.764063. PMID: 34956050

Dec 9

Analgesic use and circulating estrogens, androgens, and their metabolites in the Women's Health Initiative Observational Study. Hurwitz LM, Shadyab AH, Tabung FK, Anderson GL, Saquib N, Wallace RB, Wild RA, Pfeiffer RM, Xu X, Trabert B. Cancer Prev Res (Phila). 2021 Dec 9:canprevres.CAPR-21-0264-A.2021. doi: 10.1158/1940-6207.CAPR-21-0264. PMID: 34893532

Dec 8

Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial. Driver BE, Semler MW, Self WH, Ginde AA, Trent SA, Gandotra S, Smith LM, Page DB, Vonderhaar DJ, West JR, Joffe AM, Mitchell SH, Doerschug KC, Hughes CG, High K, Landsperger JS, Jackson KE, Howell MP, Robison SW, Gaillard JP, Whitson MR, Barnes CM, Latimer AJ, Koppurapu VS, Alvis BD, Russell DW, Gibbs KW, Wang L, Lindsell CJ, Janz DR, Rice TW, Prekker ME, Casey JD; BOUGIE Investigators and the Pragmatic Critical Care Research Group. JAMA. 2021 Dec 8. doi: 10.1001/jama.2021.22002. PMID: 34879143
Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy. Saad NY, Al-Kharsan M, Garwick-Coppens SE, Chermahini GA, Harper MA, Palo A, Boudreau RL, Harper SQ. Nat Commun. 2021 Dec 8;12(1):7128. doi: 10.1038/s41467-021-27430-1. PMID: 34880230
Translating in vitro CFTR rescue into small molecule correctors for cystic fibrosis using the Library of Integrated Network-based Cellular Signatures drug discovery platform. Strub MD, Ramachandran S, Boudko DY, Meleshkevitch EA, Pezzulo AA, Subramanian A, Liberzon A, Bridges RJ, McCray PB Jr. CPT Pharmacometrics Syst Pharmacol. 2021 Dec 8. doi: 10.1002/psp4.12751. PMID: 34877817

Dec 7

Protein profiling of RGS6, a pleiotropic gene implicated in numerous neuropsychiatric disorders, reveals multi-isoformic expression and a novel brain-specific isoform. Ahlers-Dannen KE, Yang J, Spicer MM, Maity B, Stewart A, Koland JG, Fisher RA. eNeuro. 2021 Dec 7:ENEURO.0379-21.2021. doi: 10.1523/ENEURO.0379-21.2021. PMID: 34880111

Dec 6

BBSome: a New Player in Hypertension and Other Cardiovascular Risks. Zhao Y, Rahmouni K. Hypertension. 2021 Dec 6:HYPERTENSIONAHA12117946. doi: 10.1161/HYPERTENSIONAHA.121.17946. PMID: 34865504

Dec 5

Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies. Dampalla CS, Rathnayake AD, Perera KD, Jesri AM, Nguyen HN, Miller MJ, Thurman HA, Zheng J, Kashipathy MM, Battaile KP, Lovell S, Perlman S, Kim Y, Groutas WC, Chang KO. J Med Chem. 2021 Dec 5. doi: 10.1021/acs.jmedchem.1c01037. PMID: 34865476

Dec 3

Using nasal povidone-iodine to prevent bloodstream infections and transmission of Staphylococcus aureus among haemodialysis patients: a stepped-wedge cluster randomised control trial protocol. Racila AM, O'Shea AMJ, Nair R, Dukes K, Herwaldt LA, Boyken L, Diekema D, Ward MA, Cobb J, Jacob J, Pegues D, Bleasdale S, Vijayan A, Mutneja A, Fraer M, O'Connell-Moore D, Tolomeo P, Mendez M, Jaworski E, Schweizer ML. BMJ Open. 2021 Dec 3;11(12):e048830. doi: 10.1136/bmjopen-2021-048830. PMID: 34862278

Dec 2

The impact of KRAS mutation, microsatellite instability, and tumor laterality on the prognosis of nonmetastatic colon cancer. Tran CG, Goffredo P, Mott SL, Hart A, You YN, Vauthey JN, Weigel RJ, Hassan I. Surgery. 2021 Dec 2:S0039-6060(21)01044-8. doi: 10.1016/j.surg.2021.10.043. PMID: 34865865

Dec 1

2021 Publications

2021 Publications

January 2021

February 2021

March 2021

April 2021

May 2021

June 2021

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September 2021

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December 2021